Abstract: Methods, systems, and computer programs encoded on a computer storage medium, for improving EEG measurements by identifying artifacts present in EEG measurements and providing a real-time indication to a user of likely artifacts in EEG measurements are described. EEG measurements of a patient can be obtained by placing a wearable device or EEG cap on a patient's head. Sensors in the cap provide EEG data to a computing device that processes the data to identify one or more artifacts in the EEG data. The artifacts can be identified by conducting one or more operations of determining the signal to noise ratio of the line noise, calculating mutual information between sensor pairs, and applying the p-welch method. Based on the types of artifacts identified, the computing device can output an indicator that provides feedback to the technician performing an EEG test to make adjustments to the test setup.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for synchronizing neuroelectric measurements with diagnostic content presentation by performing actions that include causing a presentation system to present diagnostic content a user, where the diagnostic content includes: a first content frame prompting the user to perform a physical task, a second content frame including electroencephalogram (EEG) synchronization content, the second content frame sequentially following the first content frame, and a third content frame indicating an outcome of the physical task, the third content frame sequentially following the second content frame. The actions include obtaining, from a brainwave sensor, EEG signals of the user during presentation of the diagnostic content. The actions include providing the EEG signals as input features to a machine learning model that is trained to predict a psychological state of the user based on the EEG signals.

Abstract: Methods, systems, and computer programs encoded on a computer storage medium, for improving EEG measurements by identifying artifacts present in EEG measurements and providing a real-time indication to a user of likely artifacts in EEG measurements are described. EEG measurements of a patient can be obtained by placing a wearable device or EEG cap on a patient's head. Sensors in the cap provide EEG data to a computing device that processes the data to identify one or more artifacts in the EEG data. The artifacts can be identified by conducting one or more operations of determining the signal to noise ratio of the line noise, calculating mutual information between sensor pairs, and applying the p-welch method. Based on the types of artifacts identified, the computing device can output an indicator that provides feedback to the technician performing an EEG test to make adjustments to the test setup.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining feature sets for a first number of diagnostic trials performed with a patient for diagnostic testing, wherein each feature set includes one or more features of electroencephalogram (EEG) signals measured from the patient while the patient is presented with trial content known to stimulate one or more desired human brain systems. Iteratively providing different combinations of the feature sets as input data to a diagnostic machine learning model to obtain model outputs, each model output corresponding to a particular one of the combinations. Determining, based on the model outputs, a consistency metric, the consistency metric indicating whether a quantity of feature sets in the combinations is sufficient to produce accurate output from the diagnostic machine learning model. Selectively ending the diagnostic testing with the patient based on a value of the consistency metric.

Abstract: The present invention provides BRACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.

Abstract: The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.