Abstract: The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.

Abstract: The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.

Abstract: The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.

Abstract: Synthetic transcriptions factors for modulation of frataxin expression and methods of use are described herein.

Abstract: The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.

Abstract: A method of estimating at least one property of an earth formation includes: constructing a matrix model of a formation; constructing a shale model of the formation, the shale model including an estimation of a concentration of at least one trace element; combining the first model and the second model to generate a formation model; and comparing measured pulsed neutron data with the mixed model to estimate the at least one property.

Abstract: A method of evaluating a cased borehole in an earth formation includes: emitting at least one acoustic signal into the borehole via an acoustic source and detecting a return acoustic signal via an acoustic sensor, the borehole including a casing and a casing support material disposed between the casing and a borehole wall; emitting a neutron flux via a neutron source into the borehole and detecting a radiation signal via a radiation detector, the radiation signal including induced gamma radiation resulting from neutron interactions; and identifying a casing support material characteristic based on the return acoustic signal and the radiation signal.

Abstract: A method of estimating fluid composition in an earth formation includes: generating at least one pulsed neutron measurement by a pulsed neutron tool; estimating a pulsed neutron fluid saturation by analyzing the at least one pulsed neutron measurement via a pulsed neutron model of the earth formation, the pulsed neutron model including expected pulsed neutron measurements relative to selected fluid composition and properties; comparing the pulsed neutron fluid saturation to a reference fluid saturation estimated via a downhole tool; adjusting the pulsed neutron model to at least substantially eliminate a difference between the pulsed neutron fluid saturation and the reference fluid saturation by adjusting at least one of the selected fluid composition and the selected fluid properties; and estimating at least one of the fluid composition and the fluid properties based on the adjusted model.

Abstract: A method for estimating a property of an earth formation, the method includes: conveying a carrier through a borehole penetrating the earth formation; irradiating the formation with neutrons from a neutron source disposed at the carrier; detecting a first signal from the formation due to the irradiating using a first radiation detector, the first signal being related to a saturation of a fluid in the formation; detecting a second signal from an element in the formation due to the irradiating using a second radiation detector, the second signal being related to an element emitting the second signal in the formation; and estimating the property from the first signal and the second signal.

Abstract: A method for estimating a parameter of interest of an earth formation having a fluid contained in pores of the earth formation, the method includes: conveying a carrier through a borehole penetrating the earth formation; irradiating the earth formation with neutrons from a neutron source disposed at the carrier; measuring radiation emitted from the earth formation resulting from the irradiating using at least one detector; calculating or determining a mathematical parameter from radiation measured by the at least one detector; predicting values of the mathematical parameter over a range of values of an earth formation property; and comparing the mathematical parameter to the predicted values to estimate the parameter of interest.

Abstract: A method for estimating a property of an earth formation, the method includes: conveying a carrier through a borehole penetrating the earth formation; irradiating the formation with neutrons from a neutron source disposed at the carrier; detecting a first signal from the formation due to the irradiating using a first radiation detector, the first signal being related to a saturation of a fluid in the formation; detecting a second signal from an element in the formation due to the irradiating using a second radiation detector, the second signal being related to an element emitting the second signal in the formation; and estimating the property from the first signal and the second signal.

Abstract: A method of evaluating a cased borehole in an earth formation includes: emitting at least one acoustic signal into the borehole via an acoustic source and detecting a return acoustic signal via an acoustic sensor, the borehole including a casing and a casing support material disposed between the casing and a borehole wall; emitting a neutron flux via a neutron source into the borehole and detecting a radiation signal via a radiation detector, the radiation signal including induced gamma radiation resulting from neutron interactions; and identifying a casing support material characteristic based on the return acoustic signal and the radiation signal.

Abstract: A method for estimating a parameter of interest of an earth formation having a fluid contained in pores of the earth formation, the method includes: conveying a carrier through a borehole penetrating the earth formation; irradiating the earth formation with neutrons from a neutron source disposed at the carrier; measuring radiation emitted from the earth formation resulting from the irradiating using at least one detector; calculating or determining a mathematical parameter from radiation measured by the at least one detector; predicting values of the mathematical parameter over a range of values of an earth formation property; and comparing the mathematical parameter to the predicted values to estimate the parameter of interest.

Abstract: A method of estimating fluid composition in an earth formation includes: generating at least one pulsed neutron measurement by a pulsed neutron tool; estimating a pulsed neutron fluid saturation by analyzing the at least one pulsed neutron measurement via a pulsed neutron model of the earth formation, the pulsed neutron model including expected pulsed neutron measurements relative to selected fluid composition and properties; comparing the pulsed neutron fluid saturation to a reference fluid saturation estimated via a downhole tool; adjusting the pulsed neutron model to at least substantially eliminate a difference between the pulsed neutron fluid saturation and the reference fluid saturation by adjusting at least one of the selected fluid composition and the selected fluid properties; and estimating at least one of the fluid composition and the fluid properties based on the adjusted model.

Abstract: A method of estimating at least one property of an earth formation includes: constructing a matrix model of a formation; constructing a shale model of the formation, the shale model including an estimation of a concentration of at least one trace element; combining the first model and the second model to generate a formation model; and comparing measured pulsed neutron data with the mixed model to estimate the at least one property.

Abstract: A system and method for analyzing DNA binding specificities is provided. The potential binding motifs are compared to a plurality of DNA sequences. The DNA sequences are plotted within a specificity landscape, which provides details otherwise unavailable, relating to binding affinities and binding specificities of the motif-sequence combination.

Abstract: A system and method for analyzing DNA binding specificities is provided. The potential binding motifs are compared to a plurality of DNA sequences. The DNA sequences are plotted within a specificity landscape, which provides details otherwise unavailable, relating to binding affinities and binding specificities of the motif-sequence combination.

Abstract: The invention provides reliable, reusable materials, system and methods for use in nucleic acid binding assays between a nucleic-acid binding assay molecule and a robust unimolecular target. In a preferred embodiment, the target is a nucleic acid-containing molecule, L1-X1-L2-X2 (where L1 is the linker to the solid support, and L2 is the linker between the two nucleotide-pairing regions, X1 and X2; L2 folds such that double-stranded DNA structure forms between X1 and X2). L2 is a polynucleotide three nucleotides in length, having the sequence GNA, where N is A, G, C, T, or U. A typical assay uses a target array, where multiple targets are bound to a solid surface. The linker, L1, of the nucleic acid target to the supporting surface is useful although it is significantly longer than suggested in the art. The length of L1 is preferably 8 to 30 nucleotides in length, more preferably from 10 to 20 nucleotides.

Abstract: The present invention particularly relates to an extract from Indian green mussel (Pema viridis) which induces differentiation and maturation of dendritic cells wherein said dendritic cells can be used in vaccination, cancer therapy and other immunomodulatory regiments.