Patents by Inventor Zacharia S. Cheruvallath

Zacharia S. Cheruvallath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of sulfurized oligonucleotides
    Patent number: 7723511
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 25, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar, Zacharia S. Cheruvallath
  • SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES
    Publication number: 20080293929
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Application
    Filed: April 21, 2008
    Publication date: November 27, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES
    Publication number: 20080200371
    Abstract: Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.
    Type: Application
    Filed: March 28, 2008
    Publication date: August 21, 2008
    Inventors: Zacharia S. CHERUVALLATH, Colin J. Loweth, Ruth F. Nutt, Darryl Rideout, Joseph E. Semple, Jing Wang, Feiyue Wu, Shankari Mylvaganam, Hengyi Zhu, Jianzhong Sun
  • Thiazole and thiadiazole inhibitors of tyrosine phosphatases
    Patent number: 7381736
    Abstract: Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: June 3, 2008
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Zacharia S. Cheruvallath, Colin J. Loweth, Ruth F. Nutt, Darryl Rideout, Joseph E. Semple, Jing Wang, Feiyue Wu, Shankari Mylvaganam, Hengyi Zhu, Jianzhong Sun
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7378516
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: May 27, 2008
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7227015
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: June 5, 2007
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Intermediates for the synthesis of oligonucleotide analogues
    Patent number: 6677471
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: January 13, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Synthesis of sulfurized oligonucleotides
    Publication number: 20030212267
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Application
    Filed: December 12, 2002
    Publication date: November 13, 2003
    Inventors: Douglas L Cole, Vasulinga T Ravikumar, Zacharia S Cheruvallath
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030149260
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 7, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6521775
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: February 18, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6399756
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Reagent useful for synthesizing sulfurized oligonucleotide analogs
    Patent number: 6399831
    Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole, Daniel C. Capaldi
  • Process for the synthesis of oligomeric compounds
    Publication number: 20020055623
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Application
    Filed: December 11, 2001
    Publication date: May 9, 2002
    Applicant: ISIS Pharmaceuticals. Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6326478
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 8, 1998
    Date of Patent: December 4, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Synthesis of sulfurized 2'-substituted oligonucleotides
    Patent number: 6242591
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfuiized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: June 5, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Synthesis of sulfurized oligonucleotides
    Patent number: 6114519
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: September 5, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Reagent useful for synthesizing sulfurized oligonucleotide analogs
    Patent number: 6040438
    Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: March 21, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole, Daniel C. Capaldi
  • Protecting group for synthesizing oligonucleotide analogs
    Patent number: 5959099
    Abstract: A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: September 28, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole
  • Reagent useful for synthesizing sulfurized oligonucleotide analogs
    Patent number: 5902881
    Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: May 11, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole, Daniel C. Capaldi
  • Protecting group for synthesizing oligonucleotide analogs
    Patent number: 5783690
    Abstract: A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: July 21, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole