Patents by Inventor ZACHARY A. KLASE

ZACHARY A. KLASE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for reactivating latent HIV-1 infections
    Patent number: 11554123
    Abstract: The present invention relates in part to the discovery that benzodiazepines can be used to reactivate latent HIV-1 virus that is integrated into human genome. In other embodiments, the benzodiazepine is used in combination with a histone deacetylase inhibitor (HDACi), such as but not limited to SAHA (also known as N-hydroxy-N-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat). In yet other embodiments, the combination of benzodiazepine and the HDACi synergistically reactivates latent HIV-1 virus that is integrated into human genome, with minimal or no significant toxicity associated with the dose of either agent.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: January 17, 2023
    Assignee: Saint Joseph's University
    Inventor: Zachary A. Klase
  • COMPOSITIONS AND METHODS FOR REACTIVATING LATENT HIV-1 INFECTIONS
    Publication number: 20200016168
    Abstract: The present invention relates in part to the discovery that benzodiazepines can be used to reactivate latent HIV-1 virus that is integrated into human genome. In other embodiments, the benzodiazepine is used in combination with a histone deacetylase inhibitor (HDACi), such as but not limited to SAHA (also known as N-hydroxy-N-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat). In yet other embodiments, the combination of benzodiazepine and the HDACi synergistically reactivates latent HIV-1 virus that is integrated into human genome, with minimal or no significant toxicity associated with the dose of either agent.
    Type: Application
    Filed: February 28, 2018
    Publication date: January 16, 2020
    Inventor: ZACHARY A. KLASE