Patents by Inventor Zachary Apte

Zachary Apte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180362967
    Abstract: Embodiments of a method 100 and/or system 200 or library preparation for sequencing associated with microorganisms can include: preparing a set of unique molecular identifier (UMI)-based molecules associated with one or more targets; preparing a set of sequencing-based primers; generating a set of tagged target molecules based on the set of UMI-based molecules and one or more samples associated with the one or more targets; and/or generating a set of sequencing-ready tagged target molecules based on the tagged target molecules and the set of sequencing-based primers.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 20, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Juan Jimenez, Rodrigo Ortiz, Eduardo Morales, Paulo Covarrubias, Eduardo Olivares, Nicolas Ordenes, Luis Leon
  • Publication number: 20180342322
    Abstract: Embodiments of a method and/or system for characterizing one or more appendix-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with the one or more appendix-related conditions, based on the microorganism dataset, where performing the characterization process can additionally or alternatively include performing an appendix-related characterization process for the one or more appendix-related conditions, and/or determining one or more therapies.
    Type: Application
    Filed: July 18, 2018
    Publication date: November 29, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Rodrigo Ortiz, Catalina Valdivia, Inti Pedroso, Paz Tapia
  • Publication number: 20180311310
    Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.
    Type: Application
    Filed: March 7, 2018
    Publication date: November 1, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Melissa Alegria, Valeria Marquez, Eduardo Morales, Rodrigo Ortiz, Janet Torres, Paulo Covarrubias, Javier Gimpel, Ingrid Araya
  • Publication number: 20180286520
    Abstract: Embodiments of a method and/or system for characterizing one or more sleep-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with the one or more sleep-related conditions, based on the microorganism dataset, where performing the characterization process can additionally or alternatively include performing a sleep-related characterization process for the one or more sleep-related conditions, and/or determining one or more therapies S140.
    Type: Application
    Filed: June 4, 2018
    Publication date: October 4, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Inti Pedroso, Catalina Valdivia, Rodrigo Ortiz, Paz Tapia
  • Patent number: 10073952
    Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: September 11, 2018
    Assignee: uBiome, Inc.
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman, Siavosh Rezvan Behbahani
  • Publication number: 20180137240
    Abstract: Embodiments of a method and/or system for improving fragment assembly and/or sequence identification includes: collecting a sample including a set of nucleic acid components associated with a set of microorganisms; generating a set of tagged sequence fragments; amplifying the set of tagged sequence fragments and sequencing the set of tagged sequence fragments; based upon the set of identifier tags, generating a set of branched assemblies of candidate sequence fragments, wherein each of the set of branched assemblies includes a set of ordered nodes and a set of branches distributed across the set of nodes; implementing a threshold criterion to reduce the set of branched assemblies to a set of branch-reduced assemblies; and identifying a set of sequences corresponding to the set of branch-reduced assemblies and/or generating an analysis informative of the set of microorganisms associated with the sample.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 17, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Rodrigo Ortiz
  • Publication number: 20180137931
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 17, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180137239
    Abstract: Embodiments of a system and method for characterizing a panel of conditions associated with a set of taxa related to microorganisms can include a taxonomic database including reference microbiome features for the set of taxa associated with the panel of conditions; a handling operable to collect a container including biological material from a user, the handling system comprising a sequencer system operable to determine a microorganism sequence dataset; and a panel characterization system operable to: determine user microbiome features for the set of taxa for the user based on the microorganism sequence dataset, generate a comparison between the user microbiome features and the reference microbiome features, and determine a panel characterization for the panel of conditions for the user based on the comparison; and a treatment system operable to promote a therapy for a condition of the panel of conditions based on the panel characterization.
    Type: Application
    Filed: September 18, 2017
    Publication date: May 17, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Laurens Kraal, Francisco Ossandon, Juan Pablo Cardenas, Elisabeth Bik, Audrey Goddard
  • Publication number: 20180137930
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 17, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122512
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122513
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122510
    Abstract: Embodiments of a method and/or system for characterizing a diet-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more diet-related conditions for the set of users; and performing a diet-related characterization process for the one or more diet-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
    Type: Application
    Filed: December 15, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Catalina Valdivia, Rodrigo Ortiz, Inti Pedroso, Victoria Dumas, Paz Tapia, Eduardo Morales
  • Publication number: 20180122514
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122887
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122515
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman
  • Publication number: 20180122511
    Abstract: Embodiments of a method and/or system for characterizing a microorganism-related condition (e.g., human behavior condition, disease-related condition, etc.) for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more microorganism-related conditions for the set of users; and performing a microorganism-related characterization (e.g., human behavior characterization, disease-related characterization, etc.) process for the one or more microorganism-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
    Type: Application
    Filed: December 18, 2017
    Publication date: May 3, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Catalina Valdivia, Rodrigo Ortiz, Inti Pedroso, Victoria Dumas, Paz Tapia, Eduardo Morales
  • Publication number: 20180114592
    Abstract: Embodiments of a method and/or system for characterizing an allergy-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more allergy-related conditions for the set of users; and performing an allergy-related characterization process for the one or more allergy-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 26, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Catalina Valdivia, Rodrigo Ortiz, Inti Pedroso, Victoria Dumas, Paz Tapia, Eduardo Morales
  • Publication number: 20180102187
    Abstract: Embodiments of a method and/or system for characterizing a headache-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more headache-related conditions for the set of users; and performing a characterization process for the one or more headache-related conditions, based on the supplementary dataset and microbiome features extracted from the microbiome dataset.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 12, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Rodrigo Ortiz, Catalina Valdivia, Victoria Dumas, Paz Tapia
  • Publication number: 20180087051
    Abstract: Embodiments of a method and system for improved microbiome sequencing can include: generating guide RNA complexes for a set of targets corresponding to a set of taxa associated with the microorganism-related condition; processing the biological sample with the gRNA complexes to generate microorganism nucleic acid fragments comprising a set of end regions associated with the set of targets; ligating the set of end regions with a set of adapters sharing an adapter sequence; and amplifying the set of targets based on the ligated set of end regions and a set of primers sharing a primer sequence associated with the adapter sequence.
    Type: Application
    Filed: September 27, 2017
    Publication date: March 29, 2018
    Inventors: Zachary Apte, Jessica Richman, Daniel Almonacid, Audrey Goddard, Rodrigo Ortiz, Sara Bird, Eduardo Morales
  • Publication number: 20180090552
    Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 29, 2018
    Inventors: Zachary Apte, Daniel Almonacid, Jessica Richman