Patents by Inventor Zachary Buchwald

Zachary Buchwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Suppression of bone loss by introducing FoxP3+ CD8 T-cells (TcREG)
    Patent number: 9713633
    Abstract: Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist such as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: July 25, 2017
    Assignee: Saint Louis University
    Inventors: Rajeev Aurora, Zachary Buchwald
  • Suppression of bone loss by introducing FoxP3+ CD8 T-cells (Tc)
    Patent number: 9144599
    Abstract: Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) either in vivo or ex vivo. The FoxP3+ CD8 T-cells (TcREG) are provided to the patient to subsequently regulate osteoclast function, thereby establishing a bi-directional regulatory loop between osteoclasts and FoxP3+ CD8 T-cells (TcREG).
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: September 29, 2015
    Assignee: Saint Louis University
    Inventors: Rajeev Aurora, Zachary Buchwald, Jennifer Kiesel
  • Suppression of Bone Loss by Introducing FoxP3+ CD8 T-cells (TcREG)
    Publication number: 20140093475
    Abstract: Systems and methods for inhibiting bone loss using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) either in vivo or ex vivo. The FoxP3+ CD8 T-cells (TcREG) are provided to the patient to subsequently regulate osteoclast function, thereby establishing a bi-directional regulatory loop between osteoclasts and FoxP3+ CD8 T-cells(TcREG).
    Type: Application
    Filed: October 1, 2013
    Publication date: April 3, 2014
    Applicant: Saint Louis University
    Inventors: Rajeev Aurora, Zachary Buchwald, Jennifer Kiesel