Abstract: An aspect of the disclosure is related to a cleaning composition and a device to apply a cleaning composition. The device may include a container containing a cleaning composition to clean a surface of a dental appliance in an oral cavity, an applicator portion to apply the cleaning composition to the surface of the dental appliance in the oral cavity and a gap between the dental appliance and the oral cavity, the applicator having a portion to be deformed based on the gap width of the gap to be inserted into the gap to apply the cleaning composition in the gap, and an extruder to extrude the cleaning composition in the container through an outlet to the applicator portion and the portion, wherein the cleaning composition is essentially free of a dental abrasive agent, wherein the dental abrasive agent is a solid particle having a hardness harder than the hardness of the surface of the dental appliance.

Abstract: Comparison of common sequencing reads from sequencing based on partition-based barcoding can be used to improve sequencing results. Increased loading of barcodes per partition can also improve sequencing results.

Abstract: Comparison of common sequencing reads from sequencing based on partition-based barcoding can be used to improve sequencing results. Increased loading of barcodes per partition can also improve sequencing results.

Abstract: Provided are methods for detecting the presence of multiple barcoded solid supports in partitions, the method comprising providing a plurality of partitions wherein at least some partitions comprises multiple solid supports, where each solid support is linked to different solid support oligonucleotides, the solid support oligonucleotides comprising a barcode unique for the solid support; synthesizing a complementary sequence of the oligonucleotides to produce a double-stranded polynucleotide having barcodes from two of the solid support oligonucleotides; and sequencing one or both strands of the double-stranded polynucleotides, wherein sequences comprising two different barcodes indicates the presence of two solid supports in the same partition. Also provided are compositions and methods for producing the oligonucleotides.

Abstract: Comparison of common sequencing reads from sequencing based on partition-based barcoding can be used to improve sequencing results. Increased loading of barcodes per partition can also improve sequencing results.