Abstract: Methods, systems, and computer-readable media for multi-domain, multi-modal data segmentation, and automatically generating and refining hypotheses. The method receives data from a plurality of data sources; synthesizing the receive data; identifying trigger event data based on the synthesized data; generating an episode based on a segmentation of the synthesized data and trigger event data; and identifying at least one set of observational features associated with the episode based on the synthesized data and a relevancy metric. The method also includes iteratively generating a hypothesis based on the observational features using machine learning, predicting an outcome based on the hypothesis using machine learning, generating an outcome measure, and validating the hypothesis based on the outcome measure.

Abstract: The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula: wherein R1 comprises a chelating agent that is chelated to a metal atom, wherein the metal atom is an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days. In one such embodiment, a is 1, n is 18, m is 0, b is 1, and R2 is —N+(CH3)3.

Abstract: Present embodiments relate to an unfinished firearm. More specifically, but without limitation, present embodiments relate to an unfinished firearm frame which may be constructed to define a useable firearm.

Abstract: This invention discloses embodiments which disclose a handgun frame conversion and adapter system which provides for the conversion of use of a handgun frame from use with a first slide to use with a second and dissimilar slide (such as allowing a Glock® Gen 1, Gen 2 or Gen 3 slide to be used on a Gen 4 or Gen 5 Glock® compatible frame). Aspects of this frame conversion system include a conversion adapter which is installable and removable from the frame portion of the handgun, thereby allowing any one of a number of handgun slides to be mounted or installed on one frame.

Abstract: Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.

Abstract: Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.

Abstract: Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.