Patents by Inventor Zachary D. Smith

Zachary D. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250146086
    Abstract: Methods for quantifying DNA methylation that may be utilized for screening for diseases (e.g., cancer), diagnosing diseases (e.g., cancer type), monitoring progression of a disease, and monitoring response to a therapeutic treatment.
    Type: Application
    Filed: January 13, 2025
    Publication date: May 8, 2025
    Inventors: Alexander Meissner, Zachary D. Smith, Franziska Michor, Jiantao Shi
  • Patent number: 12195802
    Abstract: Methods for quantifying DNA methylation that may be utilized for screening for diseases (e.g., cancer), diagnosing diseases (e.g., cancer type), monitoring progression of a disease, and monitoring response to a therapeutic treatment.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: January 14, 2025
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Alexander Meissner, Zachary D. Smith, Franziska Michor, Jiantao Shi
  • Publication number: 20240327922
    Abstract: The present invention relates to methods of characterizing cell-free DNA (cfDNA), detecting cancer, detecting the eradication of cancer, and determining a probability distribution of haplotypes. The methods use the data from genomic sequences from CpG Islands (CGI) methylated in the genome of extraembryonic ectoderm (ExE) to determine a proportion of fully methylated haplotypes in order to characterize the cfDNA sample and detect certain cancers.
    Type: Application
    Filed: December 17, 2021
    Publication date: October 3, 2024
    Inventors: Jiantao Shi, Zachary D. Smith, Alexander Meissner, Franziska Michor
  • Publication number: 20220187813
    Abstract: A computer implemented method for predicting equipment failure by monitoring equipment data, the method comprising: generating a first set of predictions by processing equipment data via a plurality of first models of data analysis and machine learning techniques; generating a second set of predictions by processing equipment data via a plurality of second models of data analysis and machine learning techniques; generating, using machine learning techniques, a consensus decision by comparing the first set of predictions and the second set of predictions; estimating, using machine learning techniques, a level of confidence for the consensus decision; and selectively disclosing the consensus decision qualifying a confidence threshold.
    Type: Application
    Filed: December 10, 2020
    Publication date: June 16, 2022
    Applicant: Caterpillar Inc.
    Inventors: Andrei Khurshudov, Tyler P. Jewell, Zachary D. Smith
  • Publication number: 20200109456
    Abstract: Methods for quantifying DNA methylation that may be utilized for screening for diseases (e.g., cancer), diagnosing diseases (e.g., cancer type), monitoring progression of a disease, and monitoring response to a therapeutic treatment.
    Type: Application
    Filed: May 14, 2018
    Publication date: April 9, 2020
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Alexander Meissner, Zachary D. Smith, Franziska Michor, Jiantao Shi