Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: A rigid polymeric modular flooring plank that contains chlorinated polyvinyl chloride (CPVC) in the core or base layer. The rigid polymeric modular flooring plank has at least a polymeric core or base layer, a decorative layer, and a wear layer located above the decorative layer. The CPVC can offset the negative effects from any plasticizer present in the core layer, and thus permits the core layer to include plasticized material such as from recycled or reclaimed sources including rework and scrap materials. Methods of making the planks are further described. A method to control dimensional stability of a polymeric flooring plank is further described.

Abstract: A method for securing a graft to a bone. The method includes forming a tunnel in the bone, positioning the graft in the tunnel, securing the graft in the tunnel with an anchor, and inserting biological material in a bore formed in the anchor.

Abstract: A tissue repair assembly for repairing tissue. The tissue repair assembly includes a rotatable anchor for insertion through a tissue tear on a surface of the tissue, a threaded fastener for insertion into the tissue, the threaded fastener having a longitudinal bore and a plurality of apertures communicating with the bore, and a flexible member coupled to the rotatable anchor and passing through the bore such that tensioning the flexible member compresses the tear.

Abstract: A fixation device for securing tissue to a bone. The fixation device includes an anchor having a hollow body defining a longitudinal passage, and a plug configured to be received in at least a portion of the passage. The body comprises a cylindrical portion and a tapered tip portion. The cylindrical portion comprises a plurality of thin-walled window covers such that after implantation the window covers are resorbed first relative to other portions of the cylindrical portion for defining a plurality of apertures on the cylindrical portion.