Abstract: A method of storing a sterile corticotropin composition at a temperature of 2° to 8° C., warming the sterile corticotropin composition to a temperature of 18° to 26° C., injecting 80 United States Pharmacopeia (USP) units of the sterile corticotropin composition into a human subject, wherein the corticotropin comprises amino acids 1-39 of SEQ ID NO: 1, or wherein the sterile corticotropin composition has not more than 0.05 USP Vasopressin Units/USP Corticotropin Units, or wherein the sterile corticotropin composition comprises acidified WFI having a pH of 2.8 to 3.2.

Abstract: A sterile preparation of purified corticotropin and methods relating thereto in which the preparation includes corticotropin extracted from a whole porcine pituitary gland including both anterior and posterior portions, and having proteins or peptides having a molecular weight higher than 4.6 kDa removed. Methods of manufacturing, testing, increasing stability, storage, and use of the purified corticotropin are also provided.

Abstract: A method of warming a vial containing a sterile corticotropin composition from a temperature of 2° to 8° C. to a temperature of 18° to 26° C., withdrawing the sterile corticotropin composition from the vial with a first needle having a first gauge size with a first diameter, replacing the first needle with a second needle having a second gauge size with a second diameter that is different from the first diameter, and injecting 80 (United States Pharmacopeia) USP units of the sterile corticotropin composition into a human subject.

Abstract: A method of storing and warming a sterile corticotropin composition by storing the sterile corticotropin composition in a multiple-dose vial comprising 80 USP units/mL of the sterile corticotropin composition, wherein the vial comprises a rubber stopper coated with cross-linked silicones, at a temperature of 2° to 8° C.; and warming the vial to a temperature of 18° to 26° C., wherein the corticotropin comprises amino acids 1-39 of SEQ ID NO: 1, or wherein the sterile corticotropin composition has not more than 0.05 USP Vasopressin Units/USP Corticotropin Units.

Abstract: A co-fueling nozzle incorporating dual spouts, having a nozzle housing, a pair of fuel flow paths provided through the housing, a separate poppet and automatic shut off valve operatively associated with each flow path, such that when fuel or additive flows through the various flow paths, it is dispensed out of separate nozzle spouts, when fuel dispensing is initiated. A single actuating lever operates to open or close the poppet valves of the nozzle, and the actuating lever connects with a pair of independent actuators, that engage with their respective poppet valves and automatic shut off valves, to provide for simultaneous or independent opening and closing of the poppet valves, to allow for simultaneous or separate flow of fuel or additives through the nozzle for co-fueling of a vehicle fuel tank or tanks.

Abstract: A co-fueling nozzle incorporating dual spouts, having a nozzle housing, a pair of fuel flow paths provided through the housing, a separate poppet and automatic shut off valve operatively associated with each flow path, such that when fuel or additive flows through the various flow paths, it is dispensed out of separate nozzle spouts, when fuel dispensing is initiated. A single actuating lever operates to open or close the poppet valves of the nozzle, and the actuating lever connects with a pair of independent actuators, that engage with their respective poppet valves and automatic shut off valves, to provide for simultaneous or independent opening and closing of the poppet valves, to allow for simultaneous or separate flow of fuel or additives through the nozzle for co-fueling of a vehicle fuel tank or tanks.