Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A prosthetic heart valve includes an inner frame having a longitudinal axis, a plurality of prosthetic leaflets coupled to the inner frame, the plurality of prosthetic leaflets configured to allow blood to flow through the inner frame in an antegrade direction along the longitudinal axis and to substantially block blood from flowing through the inner frame in a retrograde direction along the longitudinal axis, an outer frame connected to the inner frame, and a sealing feature coupled to the inner frame at a coupling point and extending partially, but not completely, between the coupling point and a point of the outer frame that is radially outward of the coupling point in a direction substantially orthogonal to the longitudinal axis, and wherein in an implanted condition, the sealing feature is positioned such that backpressure from ventricular systole acts on the sealing feature.

Abstract: The subject technology detects anomalies in media campaign configuration settings. The anomaly detection system may leverage one or more deep learning models to detect anomalies and identify particular configuration settings that contribute to the detected anomalies. In various embodiments, two or more of the deep learning models may be combined into an ensemble model that boosts the accuracy of anomaly predictions made by the anomaly detection system. The anomaly detection system may review the configuration settings of media campaigns during the configuration process and before the media campaigns run on a publication system in order to reduce the amount of unsuccessful campaigns and minimize the amount of wasted resources spent on running campaigns that have a low likelihood of achieving user defined goals.

Abstract: A food delivery system includes a food delivery container and a cell phone programmed to monitor for unauthorized access to food content provided in the food delivery container, once secured. The food delivery container has an internal volume, an opening, a cover to cover the opening to prevent access, and uncover the opening to allow access, a device for securing the cover and a sensing device for detecting whether the cover, after being positioned to cover the opening, is (still) secured over the opening, in reliance upon a state of the device for securing. The device for securing first implements a pairing or synchronizing operation with the cell phone. If the sensing device detects that the cover is not secured over the opening by the device for securing, after first being secured and armed thereon, the cell phone determines whether an authorized access has occurred.

Abstract: The present invention relates to methods for treating or preventing atherosclerotic cardiovascular disease and other conditions associated with elevated levels of lipoprotein (a) (Lp(a)) using RNAi constructs targeting the LPA gene, which encodes apolipoprotein(a), a component of Lp(a) particles. In particular, the present invention relates to methods for reducing serum Lp(a) levels and reducing the risk of cardiovascular events in patients with elevated levels of Lp(a) comprising administering an LPA-targeted RNAi construct according to specific dosage regimens. Pharmaceutical compositions comprising the LPA-targeted RNAi constructs for use in the methods are also disclosed.

Abstract: This document describes apparatuses that include integrated memory card ejector and sensor ports. A first described aspect of an apparatus includes a memory card connector, a housing, and a carriage. The memory card connector includes a receiver configured to receive a memory card and an ejector assembly configured to eject the memory card from the receiver. The housing includes a sidewall that includes a memory card slot and an integrated port. The integrated port defines an outside opening of the housing. The carriage includes a slide portion slidably positioned in the integrated port and is accessible through the outside opening of the housing. The carriage includes a carriage body having an outer port, a sensor port, and an acoustic chamber defined within the carriage body. The carriage includes an ejector connector configured for contacting the ejector assembly and a sensor assembly mounted on the carriage at the sensor port.

Abstract: A pyrolysis process comprises introducing one or more chemical reactants into a reactor containing a liquid maintained at a high temperature, producing chemical products in the liquid based on the high temperature, allowing the solid product to grow in particle size, accumulating the solid product in the liquid, and removing the solid product from the reactor while retaining a substantial portion of the liquid within the reactor. The chemical products comprise a solid chemical product that is mixed with the liquid.

Abstract: In one aspect, a method for manufacturing a lattice structure for use as a propulsion catalyst includes: (a) providing a powder bed of one or more metal powder materials, (b) heating a portion of the powder bed to a temperature sufficient to melt the one or more metal powder materials, (c) forming a layer of the lattice structure, wherein the layer is formed by melting the one or more metal powder materials in a predefined pattern, (d) constructing the lattice structure, wherein the lattice structure is constructed by repeating steps (a)-(c) for each of a plurality of layers of the lattice structure until the lattice structure is constructed, and (e) removing excess materials from the constructed lattice structure.

Abstract: The subject technology identifies a series of journey event types in an online user journey, the event types including an impression event, an email event, a click event, and a website visit, and assigns an encoder to each event type. Using an assigned encoder, the technology encodes each event type to generate an encoded vector for each event type. The encoded vector is representative of at least a portion of the online user journey relating to that event type. The technology generates an encoded vector for each event type to create a set of encoded vectors, the set of encoded vectors including one or more of an impression event encoded vector, an email event encoded vector, a click event encoded vector, and a website visit encoded vector. The technology aggregates the set of encoded vectors to generate an output of the online user journey encoder, the output including a composite encoded user journey vector for training one or more attention layers to make a prediction.

Abstract: A food delivery system includes a food delivery container and a cell phone programmed to monitor for unauthorized access to food content provided in the food delivery container, once secured. The food delivery container has an internal volume, an opening, a cover to cover the opening to prevent access, and uncover the opening to allow access, a device for securing the cover and a sensing device for detecting whether the cover, after being positioned to cover the opening, is (still) secured over the opening, in reliance upon a state of the device for securing. The device for securing first implements a pairing or synchronizing operation with the cell phone. If the sensing device detects that the cover is not secured over the opening by the device for securing, after first being secured and armed thereon, the cell phone determines whether an authorized access has occurred.

Abstract: The present disclosure relates to systems and methods for experiential marketing, and more particularly, to experiential marketing that customizes experiences and events based on the specific preferences of selected consumers, comprising registering one or more consumers with an experiential marketing platform; collecting data of the one or more consumers identifying a targeted subset of the one or more consumers based on the data; identifying one or more preferred experiences of the targeted subset; and hosting an experiential marketing event relating to the one or more preferred experiences for the targeted subset.

Abstract: A baby blanket comprising a first layer of material having a first side and a second side, the first side having a first designed border, the second side having a second designed border, the first and second sides sharing a first perimeter surface; a second layer of material having a third side and a fourth side, the third side having a third designed border, the fourth side having a fourth designed border, the third and second sides sharing a second perimeter surface; the first layer of material stitched to the second layer of material at the first and second perimeter surfaces, the stitching located around the complete first and second perimeter surfaces except at a location on the top side of the first and second perimeter surfaces creating an opening extending a first length.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.

Abstract: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract: Provided are compositions and methods useful for modulation signaling through the Toll-like receptor TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.