Patents by Inventor Zachary KARTJE

Zachary KARTJE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TUNING CRISPR/CAS9 ACTIVITY WITH CHEMICALLY MODIFIED NUCLEOTIDE SUBSTITUTIONS
    Publication number: 20240229010
    Abstract: The present disclosure provides CRISPR/Cas9 ribonucicoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (traerRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
    Type: Application
    Filed: March 18, 2022
    Publication date: July 11, 2024
    Inventors: Keith Gagnon, Masad Damha, Elise Malek-Adamian, Maryam Habibian, Daniel O'Reilly, Zachary Kartje
  • IDENTIFYING NON-PRODUCTIVE SPLICE SITES
    Publication number: 20230022489
    Abstract: The present disclosure provides methods of identifying non-productive splice sites in target RNA transcripts and antisense oligonucleotides that increase the expression of said target RNA transcripts. In an embodiment, the target RNA transcript comprises ADAR, ARSA, ATPIA2, CACNAIA, DNMI, EIF2BI, EIF2B2, EIF2B5, IDUA, MFSD8, NF2, NPC1L PEXI, PRICKLE2, PRRT2, RAM, SETD5, SHANKS, SLC6A1, STXBPI, STX1B, and TCF4.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 26, 2023
    Inventors: Athma A. PAI, Jonathan K. WATTS, Kaitlyn VALLA, Eraj Shafiq KHOKHAR, Zachary KARTJE