Patents by Inventor Zachary Knight

Zachary Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KINASE ANTAGONISTS
    Publication number: 20230111917
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: March 31, 2022
    Publication date: April 13, 2023
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • PORTABLE TAILGATING GRILL
    Publication number: 20160348922
    Abstract: A portable grill adapted to be supported by a hitch of a vehicle is provided so that the portable grill is disposed outside the vehicle during use and transportation so as to not take up important storage space in the transporting vehicle. The portable grill may include a body pivotally connected to a cooperating lid so as to define a grilling space. The components of the portable grill may be made of 10 gauge steel metal and rigidly interconnected by welds to provide sufficient operable durability. Specifically, the body may provide a rigidly connected lower frame assembly having a hitch tube dimensioned and adapted to securely mount the body to the hitch of vehicle during transport and use.
    Type: Application
    Filed: May 31, 2015
    Publication date: December 1, 2016
    Inventor: Zachary KNIGHT
  • PI3 kinase antagonists
    Patent number: 9493467
    Abstract: The present invention provides novel PI3-Kinase antagonists having the formula: and methods of use thereof.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: November 15, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat
  • Methods and Compositions for Activity Dependent Transcriptome Profiling
    Publication number: 20150141274
    Abstract: Disclosed herein are methods, compositions, and kits for isolating actively translated mRNA from heterogeneous cell populations. Also disclosed herein are methods, compositions, and kits for identifying cell types that respond to stimuli in heterogeneous cell populations.
    Type: Application
    Filed: May 9, 2013
    Publication date: May 21, 2015
    Inventors: Jeffrey M. Friedman, Zachary A. Knight, Keith Tan, Kivan Birsoy
  • P13 KINASE ANTAGONISTS
    Publication number: 20140288096
    Abstract: The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 25, 2014
    Applicant: The Regents of the University of California
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat
  • Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents
    Patent number: 8642604
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: February 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • Kinase Antagonists
    Publication number: 20110301144
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: January 29, 2011
    Publication date: December 8, 2011
    Applicant: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • KINASE ANTAGONISTS
    Publication number: 20100009963
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 14, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: ZACHARY A. KNIGHT, BETH APSEL, KEVAN M. SHOKAT
  • P13 Kinase Antagonists
    Publication number: 20090270426
    Abstract: The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 29, 2009
    Applicant: Regents of the University of California
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat
  • Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists
    Patent number: 7585868
    Abstract: The present invention provides novel compounds that can be used as antagonists of a lipid kinase such as a PI3 kinase, protein tyrosine kinase, and/or protein serine-threonine kinases such as mTOR. The present invention also provides methods of using the compounds for treating various disease conditions. The compounds include those having the formula: wherein the R1, R2 and R36 are as defined herein.
    Type: Grant
    Filed: April 4, 2007
    Date of Patent: September 8, 2009
    Assignee: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • PI3 kinase antagonists
    Publication number: 20080032960
    Abstract: The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
    Type: Application
    Filed: April 4, 2007
    Publication date: February 7, 2008
    Applicant: Regents of the University of California
    Inventors: Zachary Knight, Olusegun Williams, Kevan Shokat
  • Kinase antagonists
    Publication number: 20070293516
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tryosine kinase, PI3Kinase and mTOR, or PI3Kinase, mTOR and tryosine kinase.
    Type: Application
    Filed: April 4, 2007
    Publication date: December 20, 2007
    Applicant: Regents of the University of California
    Inventors: Zachary Knight, Beth Apsel, Kevan Shokat
  • Chemo-enzymatic process for proteome-wide mapping of post-translational modification
    Publication number: 20060246531
    Abstract: The invention provides a method for mapping the location of the post-translational modifications of a post-translationally modified peptide. Also provided is a solid-phase support that includes a reagent for modifying a post-translationally modified amino acid residues of a post-translationally modified, converting it into a substrate for a peptidase.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 2, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kevan Shokat, Zachary Knight
  • Proteome-wide mapping of post-translational modifications using endopeptidases
    Publication number: 20060210978
    Abstract: The present invention provides novel endonucleases that site-specifically cleave a post-translationally modified polypeptide at a site of post-translational modification. The present invention further provides methods making and using the endonucleases, including methods of mapping post-translational modifications in the human genome.
    Type: Application
    Filed: August 14, 2003
    Publication date: September 21, 2006
    Applicant: The Regents of the University of California
    Inventors: Kevan Shokat, Zachary Knight