Abstract: An energy harvesting electronic primer (e-primer) system including smart ammunition with e-primer technology to enhance public safety from the discharge of a firearm by replacing conventional mechanical primers used for the activation of energetic materials with an electronic primer in center fire type ammunitions, grenades, bombs and other explosive devices wherein the ammunition includes an e-primer system having a firing pin, primer cup with a safety switch, antenna, piezo element, diode, capacitor, microcontroller, thermal wire, nanoenergetic and flash hole and radio transmitter circuitry wherein the mechanical force of the firing pin strikes a nanoenergetic material to activate the initial phase of an energetic train unless the e-primer is neutralized by a radio or acoustic signal captured by the antenna mounted within the ammunition where the radio signal includes a deactivation code to neutralize the ammunition. when located in a space specifically designed to receive the radio or acoustic signal.