Abstract: In an embodiment, a cryoablation system includes a pre-cooler gas circuit, a working gas circuit isolated from the pre-cooler gas circuit, and a vacuum chamber isolated from the pre-cooler gas circuit and the working gas circuit. The cryoablation system can include a shaft having an insulated zone and a working gas expansion chamber distal to the insulated zone. The cryoablation system can further include a handle and a shaft-handle connector, wherein a proximal end of the shaft connects to the shaft-handle connector, wherein the shaft-handle connector is configured to removably attach the proximal end of the shaft to a distal end of the handle.

Abstract: In an embodiment, a method for detecting leaks in a shaft of a cryoablation system includes placing a vacuum pump in fluid communication with a return tube and a supply tube; pulling a vacuum within the supply tube and the return tube; after pulling the vacuum for a predetermined amount of time, measuring a vacuum pressure within the supply tube and the return tube; and analysis of the vacuum pressure to assist with identifying leaks in the system.

Abstract: In an embodiment, a cryoablation shaft is included having a working fluid circuit; a vacuum circuit; an insulated portion, wherein the vacuum circuit runs through the insulated portion; and an expansion chamber; a supply tube having a distal outlet in the expansion chamber, wherein fluid from the working fluid circuit travels distally down the cryoablation shaft through supply tube and expands in the expansion chamber; and a guidewire lumen including a metallic tube and a polymer sleeve configured to surround at least a portion of the metallic tube.

Abstract: Embodiments herein relate to a cryoablation probe including a pre-cooler fluid circuit; a working fluid circuit; a vacuum circuit; and a shaft. The shaft includes a supply tube and a return tube surrounding the supply tube. The return tube includes a first polymer layer, wherein the first polymer layer is configured to contain fluid from the working fluid circuit; a reinforcement layer, and a second polymer layer. Other embodiments are also included herein.