Abstract: The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.

Abstract: The present disclosure relates generally to an autonomous cell imaging and modeling platform, and more specifically to machine-learning techniques for using microscopy imaging data to continuously study live biological cells. The autonomous cell imaging and modeling platform can be applied to evaluate various cellular processes, such as cellular differentiation, optimization of cell culture (e.g., in-plate cytometry), disease modeling, histopathology imaging, and genetic and chemical screening, using a dynamic universal imaging system. In some embodiments, the platform comprises a set of label-free computational imaging techniques, self-supervised learning models, and robotic devices configured in an autonomous imaging system to study positional and morphological characteristics in particular cellular substructures of a cell culture in an efficient and non-destructive manner over time.

Abstract: A novel soybean variety, designated 5PJWA71 is provided. Also provided are the seeds of soybean variety 5PJWA71, cells from soybean variety 5PJWA71, plants of soybean 5PJWA71, and plant parts of soybean variety 5PJWA71. Methods provided include producing a soybean plant by crossing soybean variety 5PJWA71 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PJWA71, methods for producing other soybean varieties or plant parts derived from soybean variety 5PJWA71, and methods of characterizing soybean variety 5PJWA71. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PJWA71 are further provided.

Abstract: The present disclosure relates generally to an autonomous cell imaging and modeling platform, and more specifically to machine-learning techniques for using microscopy imaging data to continuously study live biological cells. The autonomous cell imaging and modeling platform can be applied to evaluate various cellular processes, such as cellular differentiation, optimization of cell culture (e.g., in-plate cytometry), disease modeling, histopathology imaging, and genetic and chemical screening, using a dynamic universal imaging system. In some embodiments, the platform comprises a set of label-free computational imaging techniques, self-supervised learning models, and robotic devices configured in an autonomous imaging system to study positional and morphological characteristics in particular cellular substructures of a cell culture in an efficient and non-destructive manner over time.

Abstract: The present disclosure relates generally to an autonomous cell imaging and modeling platform, and more specifically to machine-learning techniques for using microscopy imaging data to continuously study live biological cells. The autonomous cell imaging and modeling platform can be applied to evaluate various cellular processes, such as cellular differentiation, optimization of cell culture (e.g., in-plate cytometry), disease modeling, histopathology imaging, and genetic and chemical screening, using a dynamic universal imaging system. In some embodiments, the platform comprises a set of label-free computational imaging techniques, self-supervised learning models, and robotic devices configured in an autonomous imaging system to study positional and morphological characteristics in particular cellular substructures of a cell culture in an efficient and non-destructive manner over time.

Abstract: In one aspect, the disclosure relates to self-healing systems including at least a structural polymer, a plurality of optical fibers or polymer waveguides embedded in the structural polymer, and a plurality of micro-channels through the structural polymer, wherein the micro-channels are configured to deliver a curing composition to at least one site of damage in the system. In another aspect, the curing composition can include a photo-polymerizable liquid monomer, and, optionally, a sensitizer, a photo-initiator, and/or a toughening agent, articles comprising the same, and methods of in situ self-healing of damage including Mode-I fractures using visible irradiation from the optical fibers or polymer waveguides to photo-polymerize the liquid monomer.

Abstract: The present disclosure relates generally to an autonomous cell imaging and modeling platform, and more specifically to machine-learning techniques for using microscopy imaging data to continuously study live biological cells. The autonomous cell imaging and modeling platform can be applied to evaluate various cellular processes, such as cellular differentiation, optimization of cell culture (e.g., in-plate cytometry), disease modeling, histopathology imaging, and genetic and chemical screening, using a dynamic universal imaging system. In some embodiments, the platform comprises a set of label-free computational imaging techniques, self-supervised learning models, and robotic devices configured in an autonomous imaging system to study positional and morphological characteristics in particular cellular substructures of a cell culture in an efficient and non-destructive manner over time.

Abstract: An optical measurement system includes a wearable device configured to be worn on a body of a user and a position alignment system. The wearable device includes a support assembly and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. The position alignment system is configured to facilitate positioning of the wearable assembly at a same position on the body of the user during different use sessions of the wearable device.

Abstract: A wearable module assembly for an optical measurement system includes a first wearable module, a second wearable module, and a connector. The first and second wearable modules each include a light source configured to emit a light pulse toward a target within a body of a user, a housing that houses the light source and the plurality of detectors and includes a substantially hexagonal surface that faces a surface of the body of the user when the wearable module assembly is worn by the user, and a plurality of detectors each positioned at a fixed distance from the first light source and each configured to detect a set of photons included in the light pulse after the set of photons are scattered by the target. The connector directly connects the first wearable module and the second wearable module at mutually-facing side surfaces of the respective housings.

Abstract: Compositions and methods for prophylactically sustaining and/or maintaining a robust endocannabinoid system in patients for modulating excess inflammatory response and inflammatory diseases over the mammalian lifespan to mitigate age-related discomfort. Specifically, a method of uniquely treating inflammatory and neuropathic pain in a mammal by administering a synergistic pharmaceutical daily dosage form comprising: palmitoylethanolamide (PEA), beta-caryophyllene (BCP) and docosahexaenoic acid (DHA).

Abstract: An optical measurement system includes a wearable device configured to be worn on a body of a user and a position alignment system. The wearable device includes a support assembly and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. The position alignment system is configured to facilitate positioning of the wearable assembly at a same position on the body of the user during different use sessions of the wearable device.

Abstract: An optical measurement system includes a wearable device including a support assembly configured to be worn on a body of a user and a wearable assembly supported by the support assembly. The wearable assembly includes a plurality of light sources configured to emit a plurality of light pulses toward a target within the body of the user and a plurality of detectors each configured to receive a set of photons included in a light pulse included in the plurality of light pulses after the set of photons is scattered by the target. A position of the wearable assembly on the support assembly is adjustable.

Abstract: A novel soybean variety, designated 5PEDN51 is provided. Also provided are the seeds of soybean variety 5PEDN51, cells from soybean variety 5PEDN51, plants of soybean 5PEDN51, and plant parts of soybean variety 5PEDN51. Methods provided include producing a soybean plant by crossing soybean variety 5PEDN51 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PEDN51, methods for producing other soybean varieties or plant parts derived from soybean variety 5PEDN51, and methods of characterizing soybean variety 5PEDN51. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PEDN51 are further provided.

Abstract: A novel soybean variety, designated 5PLAL92 is provided. Also provided are the seeds of soybean variety 5PLAL92, cells from soybean variety 5PLAL92, plants of soybean 5PLAL92, and plant parts of soybean variety 5PLAL92. Methods provided include producing a soybean plant by crossing soybean variety 5PLAL92 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PLAL92, methods for producing other soybean varieties or plant parts derived from soybean variety 5PLAL92, and methods of characterizing soybean variety 5PLAL92. Soybean seed, cells, plants, germ plasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PLAL92 are further provided.

Abstract: A novel soybean variety, designated 5PVYF83 is provided. Also provided are the seeds of soybean variety 5PVYF83, cells from soybean variety 5PVYF83, plants of soybean 5PVYF83, and plant parts of soybean variety 5PVYF83. Methods provided include producing a soybean plant by crossing soybean variety 5PVYF83 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PVYF83, methods for producing other soybean varieties or plant parts derived from soybean variety 5PVYF83, and methods of characterizing soybean variety 5PVYF83. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PVYF83 are further provided.

Abstract: A novel soybean variety, designated 5PCQT33 is provided. Also provided are the seeds of soybean variety 5PCQT33, cells from soybean variety 5PCQT33, plants of soybean 5PCQT33, and plant parts of soybean variety 5PCQT33. Methods provided include producing a soybean plant by crossing soybean variety 5PCQT33 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PCQT33, methods for producing other soybean varieties or plant parts derived from soybean variety 5PCQT33, and methods of characterizing soybean variety 5PCQT33. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PCQT33 are further provided.

Abstract: A novel soybean variety, designated 5PFMW92 is provided. Also provided are the seeds of soybean variety 5PFMW92, cells from soybean variety 5PFMW92, plants of soybean 5PFMW92, and plant parts of soybean variety 5PFMW92. Methods provided include producing a soybean plant by crossing soybean variety 5PFMW92 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PFMW92, methods for producing other soybean varieties or plant parts derived from soybean variety 5PFMW92, and methods of characterizing soybean variety 5PFMW92. Soybean seed, cells, plants, germ plasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PFMW92 are further provided.

Abstract: A novel soybean variety, designated 5PDKC12 is provided. Also provided are the seeds of soybean variety 5PDKC12, cells from soybean variety 5PDKC12, plants of soybean 5PDKC12, and plant parts of soybean variety 5PDKC12. Methods provided include producing a soybean plant by crossing soybean variety 5PDKC12 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PDKC12, methods for producing other soybean varieties or plant parts derived from soybean variety 5PDKC12, and methods of characterizing soybean variety 5PDKC12. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PDKC12 are further provided.

Abstract: A novel soybean variety, designated 5PKSP40 is provided. Also provided are the seeds of soybean variety 5PKSP40, cells from soybean variety 5PKSP40, plants of soybean 5PKSP40, and plant parts of soybean variety 5PKSP40. Methods provided include producing a soybean plant by crossing soybean variety 5PKSP40 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PKSP40, methods for producing other soybean varieties or plant parts derived from soybean variety 5PKSP40, and methods of characterizing soybean variety 5PKSP40. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PKSP40 are further provided.

Abstract: A novel soybean variety, designated 5PJJE34 is provided. Also provided are the seeds of soybean variety 5PJJE34, cells from soybean variety 5PJJE34, plants of soybean 5PJJE34, and plant parts of soybean variety 5PJJE34. Methods provided include producing a soybean plant by crossing soybean variety 5PJJE34 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety 5PJJE34, methods for producing other soybean varieties or plant parts derived from soybean variety 5PJJE34, and methods of characterizing soybean variety 5PJJE34. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety 5PJJE34 are further provided.