Patents by Inventor Zachary Q. Beck

Zachary Q. Beck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoid
    Patent number: 11371035
    Abstract: This present invention relates to cultured recombinant cells comprising heterologous phosphoketolase (PKL) polypeptides that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: June 28, 2022
    Assignee: Danisco US Inc.
    Inventors: Zachary Q. Beck, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • PHOSPHOKETOLASES FOR IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOID
    Publication number: 20210139878
    Abstract: This present invention relates to cultured recombinant cells comprising heterologous phosphoketolase (PKL) polypeptides that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Application
    Filed: September 24, 2020
    Publication date: May 13, 2021
    Inventors: Zachary Q. BECK, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
    Patent number: 10988750
    Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: April 27, 2021
    Assignee: Danisco US Inc.
    Inventors: Zachary Q. Beck, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
    Patent number: 10975394
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: April 13, 2021
    Inventors: Zachary Q. Beck, Michael C. Miller, Caroline M. Peres, Yuliya A. Primak, Jeff P. Pucci, Derek H. Wells
  • PHOSPHOKETOLASES FOR IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS
    Publication number: 20190367896
    Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Application
    Filed: February 14, 2019
    Publication date: December 5, 2019
    Inventors: Zachary Q. BECK, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
    Patent number: 10364443
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: July 30, 2019
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Michael C. Miller, Caroline M. Peres, Yuliya A. Primak, Jeff P. Pucci, Derek H. Wells
  • RECOMBINANT MICROORGANISMS FOR ENHANCED PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS
    Publication number: 20190153479
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
    Type: Application
    Filed: November 26, 2018
    Publication date: May 23, 2019
    Inventors: Zachary Q. BECK, Michael C. MILLER, Caroline M. PERES, Yuliya A. PRIMAK, Jeff P. PUCCI, Derek H. WELLS
  • Phosphoketolases for improved production of acetyl coenzyme A-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
    Patent number: 10246694
    Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: April 2, 2019
    Assignees: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Zachary Q. Beck, Jeffrey W. Munos, Derek H. Wells, Jian Yao
  • Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids
    Patent number: 10138498
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: November 27, 2018
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Michael C. Miller, Caroline M. Peres, Yuliya A. Primak, Jeff P. Pucci, Derek H. Wells
  • Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
    Patent number: 10113185
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: October 30, 2018
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Caroline M. Peres, Dmitrii V. Vaviline, Andrew C. Eliot
  • PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS USING GENES ENCODING POLYPEPTIDES HAVING THIOLASE, HMG-COA SYNTHASE AND HMG-COA REDUCTASE ENZYMATIC ACTIVITIES
    Publication number: 20180002727
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
    Type: Application
    Filed: September 1, 2017
    Publication date: January 4, 2018
    Inventors: Zachary Q. BECK, Michael C. MILLER, Caroline M. PERES, Yuliya A. PRIMAK, Jeff P. PUCCI, Derek H. WELLS
  • ENGINEERED MULTIFUNCTIONAL ENZYMES AND METHODS OF USE
    Publication number: 20180002683
    Abstract: Provided are certain glycosyl hydrolase family 3 (GH3) beta-xylosidases engineered to acquire beta-glucosidase activities. Provided also are compositions comprising such multi-functional GH3 enzymes and methods of use or industrial applications thereof.
    Type: Application
    Filed: December 18, 2015
    Publication date: January 4, 2018
    Inventors: Zachary Q. Beck, Meredith K. Fujdala, Henrik Hansson, Thijs Kaper, Slavko Kralj, Amy D. Liu, Nils Egil Mikkelsen, Mats Sandgren
  • ENGINEERED MULTIFUNCTIONAL ENZYMES AND METHODS OF USE
    Publication number: 20170362621
    Abstract: Provided are certain glycosyl hydrolase family 3 (GH3) beta-glucosidase enzymes engineered to acquire beta-xylosidase activities. Provided also are compositions comprising multi-functional GH3 enzymes and methods of use or industrial applications thereof.
    Type: Application
    Filed: December 18, 2015
    Publication date: December 21, 2017
    Inventors: Zachary Q. Beck, Meredith K. Fujdala, Henrik Hansson, Thijs Kaper, Slavko Kralj, Amy D. Liu, Nils Egil Mikkelsen, Mats Sandgren
  • Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
    Patent number: 9752162
    Abstract: The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: September 5, 2017
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Michael C. Miller, Caroline M. Peres, Yuliya A. Primak, Jeff P. Pucci, Derek H. Wells
  • UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE
    Publication number: 20170198311
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Application
    Filed: September 28, 2016
    Publication date: July 13, 2017
    Inventors: Zachary Q. BECK, Caroline M. PERES, Dmitrii V. VAVILINE, Andrew C. ELIOT
  • Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
    Patent number: 9493791
    Abstract: The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: November 15, 2016
    Assignees: Danisco US Inc., The Goodyear Tire & Rubber Company
    Inventors: Zachary Q. Beck, Andrew C. Eliot, Caroline M. Peres, Dmitrii V. Vaviline
  • Increased isoprene production using the archaeal lower mevalonate pathway
    Patent number: 9464301
    Abstract: The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 11, 2016
    Assignees: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Zachary Q. Beck, Anthony R. Calabria, Michael C. Miller, Alex T. Nielsen, Dmitrii V. Vaviline
  • Compositions and methods of PGL for the increased production of isoprene
    Patent number: 9353375
    Abstract: Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 31, 2016
    Assignees: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Zachary Q. Beck, Marguerite A. Cervin, Alex T. Nielsen, Caroline M. Peres
  • PHOSPHOKETOLASES FOR IMPROVED PRODUCTION OF ACETYL COENZYME A-DERIVED METABOLITES, ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS
    Publication number: 20160068831
    Abstract: This present invention relates to cultured recombinant cells comprising a heterologous phosphoketolase (PKL) polypeptide that are capable of increased production of acetyl coenzyme A-derived metabolites, as well as methods for producing and using the same. In some embodiments, the recombinant cells further comprise one or more mevalonate (MVA) pathway polypeptides for the production of isoprenoid precursors, isoprene and isoprenoids.
    Type: Application
    Filed: April 10, 2014
    Publication date: March 10, 2016
    Inventors: Zachary Q. BECK, Jeffrey W. MUNOS, Derek H. WELLS, Jian YAO
  • Isoprene synthase variants for improved production of isoprene
    Patent number: 9273298
    Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved specific productivity. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in host cells.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 1, 2016
    Assignees: DANISCO US INC., THE GOODYEAR TIRE & RUBBER COMPANY
    Inventors: Zachary Q. Beck, David A. Estell, Jeffrey V. Miller, Christopher L. Rife, Derek H. Wells