Abstract: The present invention provides compositions and methods for treating nervous system disorders in a mammal. These compositions and methods comprise administering an effective amount of an antipurinergic agent according to a pharmacokinetic and/or pharmacodynamic method comprising an optional loading dosing regimen and a subsequent maintenance dosing regimen, to achieve efficacy in view of a dynamic, nonlinear correlation between efficacy and blood levels of the agent.

Abstract: Articles and methods as described herein include an interactive books or game assemblies that can be rearranged or reorganized while retaining cohesion. The articles can include a first page and a last page, wherein a first page is arranged at the beginning of a sequence, and a last page arranged at the end of a sequence, at least one story page following the first page, and before the last page. The at least one story page ends with a preposition or verb to allow the story pages to be organized and rearranged.

Abstract: The present invention provides methods and compositions for intranasally (IN) treating nervous system disorders such as cognitive, social, or behavioral disabilities, and neurodevelopmental disorders, More specifically, the present invention demonstrates that intranasal administration of suramin is effective to ameliorate or provide an improvement in one or more of the symptoms or manifestations associated with these disabilities and disorders.

Abstract: The present invention provides methods and compositions for treating nervous system disorders such as cognitive, social, or behavioral disabilities, and neurodevelopmental disorders. More specifically, the present invention demonstrates that administration of antipurinergic agents such as berberine, emodin, suramin, tangeretin, A-438079, A-839977, A-804598, JNJ-47965567, and KN-62 are effective to ameliorate or provide an improvement in one or more of the symptoms or manifestations associated with these disabilities and disorders.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: The present invention provides compositions and methods for treating cognitive, social, or behavioral disabilities, and neurodevelopmental disorders such as autism spectrum disorder (ASD) and other central nervous system disorders such as fragile X syndrome (FXS), fragile X-associated tremor/ataxia syndrome (FXTAS), chronic fatigue syndrome (CFS), and post-traumatic stress syndrome (PTSD). The present invention provides compositions and methods for the intranasal delivery (IN) of a therapeutically effective amount of an antipurinergic agent such as suramin for treating the disorder in a patient thereof.

Abstract: The present invention relates to topical compositions containing a therapeutically effective amount of tetrahydrocannabinol. The compositions are useful for treating a patient suffering from conditions such as pain and pruritus, particularly neuropathic or chronic inflammatory pain and/or pruritus.

Abstract: A package for containing a variety of products and for dispensing these contained products into a receptacle that can be deployed from the package, such as a bag or box for containing and dispensing consumer goods such as food items, e.g., chips or other snacks, or for containing and dispensing other consumer goods, such as granulated sugar, flour, or powdered laundry detergents. The packages are useful for dispensing the desired quantity of the contained product into the deployable receptacle without the need to reach into the package and potentially contaminate the contents of the package or one's hands.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: The present invention relates to local or topical compositions containing a therapeutically effective amount of a selective endothelin-A (ET-A) receptor antagonist or inhibitor, preferably sitaxentan, and pharmaceutically acceptable salts thereof. The compositions are useful for treating a patient that has a condition involving cutaneous fibrosis or connective tissue disease.

Abstract: The present invention relates to local or topical compositions containing a therapeutically effective amount of a selective endothelin-A (ET-A) receptor antagonist or inhibitor, preferably sitaxentan (also known as sitaxsentan), and pharmaceutically acceptable salts thereof. The compositions are useful for treating a patient that has a pigmentation disorder or irregularity.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.

Abstract: A pressure control device may include a body having a central axis extending therefrom; at least one rotatable seal within the body, the rotatable seal configured to seal against a tubular extending through the pressure control device along the central axis and rotate within the body with the tubular; at least one coil within the body wrapped at least once around the central axis, wherein the at least one coil is configured to send characteristics of the tubular to a controller; an outlet to divert fluid from an annulus, wherein the outlet being located axially below the at least one rotatable seal, wherein the controller is configured to control the at least one rotatable seal and its engagement against the tubular based on the characteristics of the tubular received by the controller.

Abstract: The present invention relates to a flexible and durable bookbinding and to methods for making bound books. More specifically, the present invention relates to books that may withstand substantial and repeated perpendicular flexure along their spine. Among other advantages, these books demonstrate improved resistance to wear and tear and normal usage to remain intact.

Abstract: The present invention relates to a flexible and durable bookbinding and to methods for making bound books. More specifically, the present invention relates to books that may withstand substantial and repeated perpendicular flexure along their spine. Among other advantages, these books demonstrate improved resistance to wear and tear and normal usage to remain intact.

Abstract: Provided herein are novel isotretinoin formulations that provide an enhanced targeted dermal delivery system for the drug isotretinoin with improved thermodynamic activity using no to a small level of ethanol relative to existing isotretinoin gel products, and methods for treatment of ichthyosis and other skin conditions using the same.