Abstract: Described here are systems and methods for testing neurostimulation settings and measuring their effects on neural activity, which may then be used to select subject-specific neurostimulation settings. In general, the present disclosure provides systems and methods that utilize neural recordings to help determine the neurostimulation settings that maximally reduce a particular neural activity.

Abstract: Neurostimulation, such as electrical and/or magnetic neurostimulation, is controlled using an adaptive real-time state space (ARTISTS) control framework to determine and/or adjust stimulation settings (e.g., stimulation waveforms). The ARTISTS control framework generally includes an adaptive autoregressive model of the nervous system's response to stimulation, an amended Kalman filter to estimate the state and coefficients of the autoregressive model, and a linear quadratic regulator to determine the stimulation waveform to be delivered.