Patents by Inventor Zachary Zwirko

Zachary Zwirko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Construction of next generation sequencing (NGS) libraries using competitive strand displacement
    Patent number: 11692219
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: July 4, 2023
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • T-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection
    Patent number: 11566282
    Abstract: The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
    Type: Grant
    Filed: October 15, 2016
    Date of Patent: January 31, 2023
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Mark Aaron Behlke, John Robert Havens, Mirna Jarosz, Zachary Zwirko, Doron Lipson, Frank Soo Juhn
  • CONSTRUCTION OF NEXT GENERATION SEQUENCING (NGS) LIBRARIES USING COMPETITIVE STRAND DISPLACEMENT
    Publication number: 20210147926
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Application
    Filed: January 5, 2021
    Publication date: May 20, 2021
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • Construction of next generation sequencing (NGS) libraries using competitive strand displacement
    Patent number: 10894979
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: January 19, 2021
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • QUANTITATIVE MICROBIAL COMMUNITY PROFILING USING MOLECULAR INVERSION PROBES WITH UNIQUE MOLECULAR IDENTIFIERS
    Publication number: 20210002718
    Abstract: The present disclosure relates to the profiling of microorganisms in an environmental sample. Specifically, the present disclosure relates to methods of using molecular inversion probes comprising unique molecular identifiers to profile microorganisms in an environmental sample. In addition, the present disclosure relates to compositions of molecular inversion probes comprising unique molecular identifiers to profile microorganisms in an environmental sample.
    Type: Application
    Filed: July 1, 2020
    Publication date: January 7, 2021
    Applicant: Trace Genomics, Inc.
    Inventors: Zachary ZWIRKO, Wyatt HARTMAN
  • Construction of next generation sequencing (NGS) libraries using competitive strand displacement
    Patent number: 10683542
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 16, 2020
    Assignee: INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • T-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection
    Patent number: 10266889
    Abstract: The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: April 23, 2019
    Assignees: ROCHE FINANCE LTD, INTEGRATED DNA TECHNOLOGIES, INC.
    Inventors: Mark Aaron Behlke, John Robert Havens, Mirna Jarosz, Zachary Zwirko, Doron Lipson, Frank Soo Juhn
  • CONSTRUCTION OF NEXT GENERATION SEQUENCING (NGS) LIBRARIES USING COMPETITIVE STRAND DISPLACEMENT
    Publication number: 20190010540
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 10, 2019
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • CONSTRUCTION OF NEXT GENERATION SEQUENCING (NGS) LIBRARIES USING COMPETITIVE STRAND DISPLACEMENT
    Publication number: 20180216177
    Abstract: The invention pertains to construction of next-generation DNA sequencing (NGS) libraries for whole genome sequencing, targeted resequencing, sequencing-based screening assays, metagenomics, or any other application requiring sample preparation for NGS.
    Type: Application
    Filed: January 26, 2018
    Publication date: August 2, 2018
    Applicant: Integrated DNA Technologies, Inc.
    Inventors: Zachary Zwirko, Yu Zheng, Mirna Jarosz, Caifu Chen, Joseph Walder
  • Tm-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION
    Publication number: 20170096706
    Abstract: The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
    Type: Application
    Filed: October 15, 2016
    Publication date: April 6, 2017
    Inventors: Mark Aaron Behlke, John Robert Havens, Scott Daniel Rose, Mirna Jarosz, Zachary Zwirko, Doron Lipson, Frank Soo Juhn
  • TM-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION
    Publication number: 20140031240
    Abstract: The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the Tm of the resultant oligonucleotide composition.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 30, 2014
    Inventors: Mark Aaron Behlke, John Robert Havens, Mirna Jarosz, Zachary Zwirko, Doron Lipson, Frank Soo Juhn