Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: The invention provides compositions and methods for high-efficiency genome editing. In some aspects, the invention provides retron-guide RNA cassettes and vectors comprising the cassettes. Also provided are host cells that have been transformed with the vectors. In other aspects, the invention provides retron donor DNA-guide molecules. In some other aspects, methods for genome editing and the screening of genetic loci are provided. In further aspects, methods and compositions are provided for the prevention or treatment of genetic diseases. Kits for genome editing and screening are also provided.

Abstract: According to some embodiments, a cable protection system to at least partially shield a cable from heat, fire, an impact or other potentially harmful event or occurrence comprises a first encompassing member configured for placement around the cable or cable bundle, wherein a first void is defined between the first encompassing member and an outside of the cable or cable bundle. The system additionally includes a second encompassing member positioned around the first encompassing member, wherein a second void is defined between the first encompassing member and the second encompassing member. Further, the system comprises one or more fill materials positioned within the second void. In some embodiments, the fill material comprises vermiculite, ceramic and/or one or more other materials. The first void permits the cable protection system to be slidably moved relative to the cable or cable bundle.

Abstract: According to some embodiments, a cable protection system to at least partially shield a cable from heat, fire, an impact or other potentially harmful event or occurrence comprises a first encompassing member configured for placement around the cable or cable bundle, wherein a first void is defined between the first encompassing member and an outside of the cable or cable bundle. The system additionally includes a second encompassing member positioned around the first encompassing member, wherein a second void is defined between the first encompassing member and the second encompassing member. Further, the system comprises one or more fill materials positioned within the second void. In some embodiments, the fill material comprises vermiculite, ceramic and/or one or more other materials. The first void permits the cable protection system to be slidably moved relative to the cable or cable bundle.