Patents by Inventor Zahi A. Fayad
Zahi A. Fayad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250205262Abstract: Provided herein are sphingolipid-loaded nanobiologics comprising: an apolipoprotein A-1 (apoA-1) or a peptide mimetic of apoA-1; a sphingolipid; and cholesterol, and uses thereof e.g., a method of innate immune regulation including stimulating a trained immunity response in a subject, and a method of treatment of cancer, comprising administering a nanobiologic composition.Type: ApplicationFiled: March 30, 2023Publication date: June 26, 2025Inventors: Abraham J. Teunissen, Willem J. Mulder, Raphaƫl Duivenvoorden, Zahi A. Fayad
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Publication number: 20150343100Abstract: Described herein is a non-invasive quantitative positron emission tomography (PET) nanoreporter technology that allows personalized therapeutic outcome prediction. In a breast cancer mouse model, it was demonstrated that co-injecting Doxil and a Zirconium-89 nanoreporter (89Zr-NRep) enabled highly precise doxorubicin (DOX) quantification. Imaging 89Zr-NRep via PET revealed remarkable Doxil accumulation heterogeneity independent of tumor size.Type: ApplicationFiled: May 27, 2015Publication date: December 3, 2015Inventors: Carlos Perez-Medina, Thomas Reiner, Jason S. Lewis, Willem J.M. Mulder, Zahi A. Fayad
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Patent number: 8097283Abstract: The present invention is directed to synthetic nanoparticles useful as imaging agents for use in MRI, CT, Gamma-scintigraphy, or optical imaging techniques. The synthetic nanoparticles comprise at least one apolipoprotein that is not an apoB lipoprotein, at least one amphipathic lipid, and at least one metallic or non-metallic contrast agent linked through a chelator to a component of the nanoparticle, wherein the one metallic or non-metallic contrast agent is present in an amount of between 5% to about 50% (w/w) of the nanoparticle, and the nanoparticle has a diameter of from about 5 nm to about 50 nm. Compositions and kits comprising the synthetic nanoparticles and methods of making and using the same are also provided.Type: GrantFiled: January 14, 2005Date of Patent: January 17, 2012Assignee: Mount Sinai School of MedicineInventors: Edward A. Fisher, Zahi A. Fayad, Kevin J. Williams
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Publication number: 20110311457Abstract: The present invention also provides methods and compositions for imaging and evaluating, e.g., blood flow or inflammation in a subject. Such evaluations are important in a number of clinical diagnoses, including assessing organ damage associated with angina pectoris, heart attack, stroke, cancer, atherosclerosis, and the like, as well as assessing vessel leakages associated with aneurisms, diffuse bleedings after trauma, and the like.Type: ApplicationFiled: July 28, 2008Publication date: December 22, 2011Applicant: NANOSCAN IMAGING, LLCInventors: H. Donlon Skerrett, Joseph Patterson, Robert W. Lee, Zahi A. Fayad
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Publication number: 20110189266Abstract: The invention provides a use of a long-circulating microvesicle comprising a sterol, partially synthetic or wholly synthetic vesicle-forming phospholipids, and a corticosteroid in water soluble form, which microvesicle has a mean particle diameter size range of between about 75 and 150 nm and which microvesicle is non-charged or negatively charged at physiological conditions, for the preparation of a medicament for the treatment of atherosclerosis and/or cardiovascular disease. A method for treating a subject suffering from, or at risk of suffering from, atherosclerosis and/or cardiovascular disease, comprising administering to said subject a therapeutically effective amount of such long-circulating microvesicles is also provided.Type: ApplicationFiled: May 26, 2009Publication date: August 4, 2011Applicants: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY, UNIVERSITEIT UTRECHT HOLDINGS B.V.Inventors: Zahi A. Fayad, Willem J. Mulder, Gerrit Storm, Josbert M. Metselaar
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Patent number: 7947307Abstract: The present invention is directed to compositions useful as imaging agents for use in monitoring atherosclerotic plaque regression using, for example, MRI, CT, Gamma-scintigraphy, or optical imaging techniques. Methods and compositions of using the same are described.Type: GrantFiled: September 16, 2005Date of Patent: May 24, 2011Assignee: Mount Sinai School of Medicine of New York UniversityInventors: Edward A. Fisher, Zahi A. Fayad, Gwendalyn Randolph, Jonathan Feig, Eugene Trogan
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Patent number: 7764814Abstract: A multicontrast-weighted acquisition of three images is performed with an MRI system. Each image is normalized and then mapped to a separate color channel. A composite color image is formed by combining all the color channels, and this image is displayed or analyzed to identify different tissue types therein.Type: GrantFiled: June 30, 2004Date of Patent: July 27, 2010Assignee: Mount Sinai School of MedicineInventors: Zahi A. Fayad, Daniel D. Samber, Venkatesh Mani, John T. Fallon, Vitalii Itskovich, Chara Itskovich, legal representative
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Patent number: 7546155Abstract: The invention includes a technique for efficient multi-slice fast spin echo image acquisition with black blood contrast in cardiac imaging. The technique includes applying a non-selective inversion pulse, followed by a re-inversion pulse that is slice-selective over a region encompassing a plurality of slice selections. Execution of a series of RF excitation pulses with fast spin echo readout is timed such that signal from blood is near a null point before acquiring data for each spatial slice. For greater contrast consistency, the flip angles for the excitation pulses occurring before the null point can be reduced, and those occurring after the null point can be increased.Type: GrantFiled: October 5, 2001Date of Patent: June 9, 2009Assignees: General Electric Company, Mount Sinai Medical CenterInventors: Thomas K. F. Foo, Zahi A. Fayad
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Patent number: 7369887Abstract: DIR imaging of blood vessels by administering a series of DIR preparation pulse modules at a repetition interval short enough that at least two DIR preparation pulse modules generally occur within each RR interval, and by acquiring image data for a plurality of slices following each DIR module.Type: GrantFiled: June 26, 2003Date of Patent: May 6, 2008Assignees: Mount Sinai School of Medicine, Siemens Medical Solutions USA, Inc.Inventors: Zahi A. Fayad, Vitalii V. Itskovich, Venkatesh Mani, Michael M. Szimtenings
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Patent number: 6915153Abstract: The magnetic resonance catheter antenna includes a first tube having a proximal end and a distal end. A litz wire has a first end and a second end and is looped within the first tube such that the first end and the second end are disposed at the proximal end. A guide wire is disposed within the first tube. A multifilament or solid wire may be used instead of a litz wire. At least the looped portion of the wire is insulated.Type: GrantFiled: March 18, 2002Date of Patent: July 5, 2005Assignees: Magna-Lab Inc., Mount Sinai School of Medicine of the City University of New YorkInventors: Lawrence A. Minkoff, Valentin Fuster, Meir Shinnar, Zahi A. Fayad, Juan J. Badimon
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Publication number: 20030023160Abstract: The magnetic resonance catheter antenna includes a first tube having a proximal end and a distal end. A litz wire has a first end and a second end and is looped within the first tube such that the first end and the second end are disposed at the proximal end. A guide wire is disposed within the first tube. A multifilament or solid wire may be used instead of a litz wire. At least the looped portion of the wire is insulated.Type: ApplicationFiled: March 18, 2002Publication date: January 30, 2003Applicant: CARDIAC M.R.I., INC.Inventors: Lawrence A. Minkoff, Valentin Fuster, Meir Shinnar, Zahi A. Fayad, Juan J. Badimon
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Patent number: 6498946Abstract: The invention includes a technique for efficient multi-slice fast spin echo image acquisition with black blood contrast in cardiac imaging. The technique includes applying a non-selective inversion pulse, followed by a re-inversion pulse that is slice-selective over a region encompassing a plurality of slice selections. Execution of a series of RF excitation pulses with fast spin echo readout is timed such that signal from blood is near a null point before acquiring data for each spatial slice. For greater contrast consistency, the flip angles for the excitation pulses occurring before the null point can be reduced, and those occurring after the null point can be increased.Type: GrantFiled: October 5, 2001Date of Patent: December 24, 2002Assignee: GE Medical Systems Global Technology Co., LLCInventors: Thomas K. F. Foo, Zahi A. Fayad
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Patent number: 6437569Abstract: A magnetic resonance image receiving coil includes a first balloon having a longitudinal axis. An internal surface of the first balloon defines an internal inflatable chamber. A second balloon has a longitudinal axis. The second balloon is disposed about the first balloon. A plurality of longitudinally extending grooves are disposed in one of an external surface of the first balloon and the internal surface of the second balloon. A first wire is disposed in at least one of the grooves. A second wire is disposed in at least a second one of the grooves. Each of the first wire and the second wire is adapted to be electrically connected to an MRI apparatus. In accordance with an alternate embodiment, the first and second wires are disposed in grooves in a sheath which is disposed between the first and second balloons. In accordance with a further alternate embodiment, the first and second wires are disposed in guide tubes that are connected to the external surface of a balloon.Type: GrantFiled: June 25, 2001Date of Patent: August 20, 2002Assignees: Magna-Lab Inc, Mount Sinai School of Medicine of the City University of New YorkInventors: Lawrence A. Minkoff, Valentin Fuster, Meir Shinnar, Zahi A. Fayad, Juan J. Badimon
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Publication number: 20020050819Abstract: A magnetic resonance image receiving coil includes a first balloon having a longitudinal axis. An internal surface of the first balloon defines an internal inflatable chamber. A second balloon has a longitudinal axis. The second balloon is disposed about the first balloon. A plurality of longitudinally extending grooves are disposed in one of an external surface of the first balloon and the internal surface of the second balloon. A first wire is disposed in at least one of the grooves. A second wire is disposed in at least a second one of the grooves. Each of the first wire and the second wire is adapted to be electrically connected to an MRI apparatus. In accordance with an alternate embodiment, the first and second wires are disposed in grooves in a sheath which is disposed between the first and second balloons. In accordance with a further alternate embodiment, the first and second wires are disposed in guide tubes that are connected to the external surface of a balloon.Type: ApplicationFiled: June 25, 2001Publication date: May 2, 2002Applicant: CARDIAC M.R.I. INC.Inventors: Lawrence A. Minkoff, Valentin Fuster, Meir Shinnar, Zahi A. Fayad, Juan J. Badimon