Abstract: According to some embodiments, a skin treatment system comprises a tower assembly including a manifold assembly, the manifold assembly comprising at least one fluid connector to secure at least one treatment fluid container, a handpiece assembly configured to hydraulically couple to the tower assembly, wherein the handpiece assembly is hydraulically coupled to the tower assembly using at least one fluid conduit, and a pressure source configured to deliver a separate fluid to the handpiece assembly, wherein the separate fluid is distinct from a fluid contained in the at least one treatment fluid container, wherein the handpiece assembly is configured to be hydraulically coupled to a vacuum source to remove spent fluid and other waste materials away from a distal end of the handpiece assembly during use, and wherein a pressure created by the separate fluid on skin tissue is configured to facilitate delivery of fluids delivered from the at least one treatment fluid container to the handpiece device deeper into a