Patents by Inventor Zaihui Zhang

Zaihui Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF HIGH PRODUCTION OF POLYPHENOLS FROM RED LETTUCES AND USES THEREOF
    Publication number: 20240147927
    Abstract: Provided herein are systems and methods for enhancement of polyphenols, such as chlorogenic acids, chicoric acid, anthocyanins, and water-soluble quercetin derivatives, production in red lettuces. Also provided are transgenic lettuce for the production of polyphenols. Also provided are parts of such transgenic lettuces, such as seeds leaves, and extracts. The disclosure also provides methods of using the new lettuces and parts thereof for protection against viral/bacterial infection (i.e., by inhibiting activities of COVID-19 virus/enzymes) diabetes, cardiovascular diseases, memory and eyesight loss, inflammation, and cancer.
    Type: Application
    Filed: February 25, 2022
    Publication date: May 9, 2024
    Inventors: Hao Chen, Tiehan Zhao, Xiaohui Yao, Zaihui Zhang, Jun Yan
  • USE OF THE AXL INHIBITOR SLC-391 AS ANTIVIRAL THERAPEUTIC AGENT
    Publication number: 20240100038
    Abstract: Provided herein are antiviral therapies using an AXL inhibitor of Formula (1), which has the following structure.
    Type: Application
    Filed: February 1, 2022
    Publication date: March 28, 2024
    Inventors: Zaihui ZHANG, Jun YAN, Zhiwei XIE
  • COMBINATION THERAPY FOR TREATING BLOOD CANCER
    Publication number: 20220031685
    Abstract: Provided herein are combination therapies for treating blood cancer, in particular, acute myeloid leukemia, by concurrently targeting Axl and BCL-2.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 3, 2022
    Inventors: Zaihui ZHANG, Xiaoyan JIANG, Katharina ROTHE, Xiaojia NIU
  • Aminopyridine derivatives as TAM family kinase inhibitors
    Patent number: 11034686
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 15, 2021
    Assignee: SignalChem Lifesciences Corporation
    Inventor: Zaihui Zhang
  • Aminopyridine derivatives as TAM family kinase inhibitors
    Patent number: 11034685
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: June 15, 2021
    Assignee: SignalChem Lifesciences Corporation
    Inventor: Zaihui Zhang
  • AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
    Publication number: 20200299287
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventor: Zaihui Zhang
  • AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
    Publication number: 20200299288
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventor: Zaihui Zhang
  • Aminopyridine derivatives as TAM family kinase inhibitors
    Patent number: 10723725
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: July 28, 2020
    Assignee: SignalChem Lifesciences Corporation
    Inventor: Zaihui Zhang
  • Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use
    Patent number: 10562859
    Abstract: Disclosed herein are compounds having the following structure useful as inhibitors of carbonic anhydrase IX (CAIX) and XII, and particularly useful for reducing or eliminating metastases see Formula (I).
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: February 18, 2020
    Assignee: SIGNALCHEM LIFESCIENCES CORPORATION
    Inventor: Zaihui Zhang
  • AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
    Publication number: 20190152965
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Inventor: Zaihui Zhang
  • Aminopyridine derivatives as TAM family kinase inhibitors
    Patent number: 10233176
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 19, 2019
    Assignee: SIGNALCHEM LIFESCIENCES CORPORATION
    Inventor: Zaihui Zhang
  • ARYL SULFONAMIDE COMPOUNDS AS CARBONIC ANHYDRASE INHIBITORS AND THEIR THERAPEUTIC USE
    Publication number: 20180201584
    Abstract: Disclosed herein are compounds having the following structure useful as inhibitors of carbonic anhydrase IX (CAIX) and XII, and particularly useful for reducing or eliminating metastases see Formula (I).
    Type: Application
    Filed: July 1, 2016
    Publication date: July 19, 2018
    Inventor: Zaihui Zhang
  • Quinazoline derivatives as TAM family kinase inhibitors
    Patent number: 9771333
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity of, e.g., the inhibition of, one or more members of the TAM family kinases.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: September 26, 2017
    Assignee: SignalChem Lifesciences Corp.
    Inventor: Zaihui Zhang
  • Benzenesulfonamide compounds and their use as therapeutic agents
    Patent number: 9630929
    Abstract: This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of sodium channel-mediated diseases or conditions, such as pain.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: April 25, 2017
    Assignee: XENON PHARMACEUTICALS INC.
    Inventors: Shaoyi Sun, Alla Yurevna Zenova, Mikhail Chafeev, Qi Jia, Zaihui Zhang, Renata Marcella Oballa
  • AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
    Publication number: 20170022189
    Abstract: Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.
    Type: Application
    Filed: November 26, 2014
    Publication date: January 26, 2017
    Inventor: Zaihui Zhang
  • Biaryl ether sulfonamides and their use as therapeutic agents
    Patent number: 9481677
    Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: November 1, 2016
    Assignee: XENON PHARMACEUTICALS INC.
    Inventors: Shifeng Liu, Thilo Focken, Navjot Chahal, Zaihui Zhang, Renata Marcella Oballa, Julia Fonarev
  • QUINAZOLINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS
    Publication number: 20160297775
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity of, e.g., the inhibition of, one or more members of the TAM family kinases.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 13, 2016
    Inventor: Zaihui Zhang
  • ORGANIC COMPOUNDS
    Publication number: 20160289191
    Abstract: The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 6, 2016
    Applicants: XENON PHARMACEUTICALS INC., NOVARTIS AG
    Inventors: Natalie Dales, Zaihui Zhang, Jianmin Fu, Duanjie Hou, Shaoyi Sun, Vishnumurthy Kodumuru, Natalia Pokrovskaia
  • Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
    Patent number: 9434720
    Abstract: Topical formulations and method of using the same are provided. The topical formulation comprises a pyrazolylbenzothiazole derivative of the following formula (1) wherein X, R1, R2, R3 and R4 are described herein.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: September 6, 2016
    Assignee: DIRMIRA (CANADA), INC.
    Inventors: Zaihui Zhang, Timothy S. Daynard, Shisen Wang, Xinyao Du, Gregory B. Chopiuk, Jun Yan, Jianxin Chen, Serguei V. Sviridov
  • Biaryl ether sulfonamides and their use as therapeutic agents
    Patent number: 9365578
    Abstract: This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: June 14, 2016
    Assignee: Xenon Pharmaceuticals Inc.
    Inventors: Shifeng Liu, Thilo Focken, Navjot Chahal, Zaihui Zhang, Renata Marcella Oballa, Julia Fonarev