Patents by Inventor Zaiwei ZONG

Zaiwei ZONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing a ß-nucleoside compound
    Patent number: 10752652
    Abstract: A method for preparing a ?-nucleoside compound, including the following steps: 1) performing a silylation reaction of a nitrogenous base or an analogue thereof in the presence of TMSOTf to give the nitrogenous base or the analogue thereof being protected by trimethylsilyl; 2) performing a direct glycosylation reaction of the reaction liquid, without being isolated, and a five- or six-membered ring saccharide or a derivative thereof closed by a hydroxyl protecting group to give a closed ?-nucleoside compound; and 3) performing a deprotection reaction to give the ?-nucleoside compound. The method uses a one-pot process to prepare the key intermediates of the ?-nucleoside compound, and the yield of materials in ?-configuration increases significantly. The method has the benefits of simple operations, being energy conservation and environment protection, and being suitable for industrial applications.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 25, 2020
    Assignee: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Zaiwei Zong, Qian Zhao, Ruifeng Yang, Gan Li, Chao Yi, Haixi Zhu
  • A METHOD FOR PREPARING A ß-NUCLEOSIDE COMPOUND
    Publication number: 20190345189
    Abstract: A method for preparing a ?-nucleoside compound, including the following steps: 1) performing a silylation reaction of a nitrogenous base or an analogue thereof in the presence of TMSOTf to give the nitrogenous base or the analogue thereof being protected by trimethylsilyl; 2) performing a direct glycosylation reaction of the reaction liquid, without being isolated, and a five- or six-membered ring saccharide or a derivative thereof closed by a hydroxyl protecting group to give a closed ?-nucleoside compound; and 3) performing a deprotection reaction to give the ?-nucleoside compound. The method uses a one-pot process to prepare the key intermediates of the ?-nucleoside compound, and the yield of materials in ?-configuration increases significantly. The method has the benefits of simple operations, being energy conservation and environment protection, and being suitable for industrial applications.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 14, 2019
    Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD.
    Inventors: Zaiwei ZONG, Qian ZHAO, Ruifeng YANG, Gan LI, Chao YI, Haixi ZHU