Patents by Inventor Zakaria Grada

Zakaria Grada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOTHERAPY OF CANCER USING GENETICALLY ENGINEERED GD2-SPECIFIC T CELLS
    Publication number: 20170027988
    Abstract: The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed. In particular cases, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and/or costimulatory molecule(s).
    Type: Application
    Filed: October 13, 2016
    Publication date: February 2, 2017
    Inventors: Malcolm Brenner, Gianpietro Dotti, Nabil M. Ahmed, Claudia Rossig, Stephen M. G. Gottschalk, Zakaria Grada
  • Immunotherapy of cancer using genetically engineered GD2-specific T cells
    Patent number: 9493740
    Abstract: The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed. In particular cases, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and/or costimulatory molecule(s).
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: November 15, 2016
    Assignee: Baylor College of Medicine
    Inventors: Malcolm Brenner, Gianpietro Dotti, Nabil Ahmed, Claudia Rossig, Stephen M. G. Gottschalk, Zakaria Grada
  • CHIMERIC ANTIGEN RECEPTOR FOR BISPECIFIC ACTIVATION AND TARGETING OF T LYMPHOCYTES
    Publication number: 20160303230
    Abstract: Embodiments of the invention include methods and compositions related to improved cells encoding a chimeric antigen receptor that is specific for two or more antigens. In certain aspects the receptor encompasses two or more non-identical antigen recognition domains. The antigens are tumor antigens, in particular embodiments.
    Type: Application
    Filed: March 22, 2016
    Publication date: October 20, 2016
    Inventors: Nabil M. Ahmed, Zakaria Grada, Meenakshi Hegde, Matthew Baker, Donald R. Shaffer
  • IMMUNOTHERAPY OF CANCER USING GENETICALLY ENGINEERED GD2-SPECIFIC T CELLS
    Publication number: 20140004132
    Abstract: The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is employed. In particular cases, the chimeric receptor comprises antibody, cytoplasmic signaling domain from the T cell receptor, and/or costimulatory molecule(s).
    Type: Application
    Filed: September 8, 2011
    Publication date: January 2, 2014
    Inventors: Malcolm Brenner, Gianpietro Dotti, Nabil Ahmed, Claudia Rossig, Stephen M.G. Gottschalk, Zakaria Grada
  • CHIMERIC ANTIGEN RECEPTOR FOR BISPECIFIC ACTIVATION AND TARGETING OF T LYMPHOCYTES
    Publication number: 20130280220
    Abstract: Embodiments of the invention include methods and compositions related to improved cells encoding a chimeric antigen receptor that is specific for two or more antigens. In certain aspects the receptor encompasses two or more non-identical antigen recognition domains. The antigens are tumor antigens, in particular embodiments.
    Type: Application
    Filed: March 7, 2013
    Publication date: October 24, 2013
    Inventors: Nabil Ahmed, Zakaria Grada, Meenakshi Hedge, Matthew Baker, Donald R. Shaffer