Patents by Inventor Zanping Wang

Zanping Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of bruton's tyrosine kinase
    Patent number: 9926299
    Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and are further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provides the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: March 27, 2018
    Assignee: Centaurus BioPharma Co., Ltd.
    Inventors: Yongxin Han, Rong Yu, Zanping Wang, Zhi Liang, Quan Hu, Li Zhu, Yuandong Hu, Yinghui Sun, Na Zhao, Yong Peng, Xiaofeng Zhai, Hong Luo, Dengming Xiao
  • Kinase modulating compounds, compositions containing the same and use thereof
    Patent number: 9550781
    Abstract: The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: January 24, 2017
    Assignees: Centaurus Biopharma Co., Ltd., Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    Inventors: Dengming Xiao, Jijun Li, Yan Zhu, Yuandong Hu, Huting Wang, Zhe Wang, Zanping Wang, Yongheng Wei, Yinghui Sun, Qiong Wu, Hui Zhang, Yong Peng, Fansheng Kong, Ying Sun, Hong Luo, Yongxin Han
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20150299171
    Abstract: The invention provides novel poly-substituted 5-membered heterocyclic compounds represented by Formula (IV), or a pharmaceutically acceptable salt, solvate, metabolites, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as selective irreversible bruton's tyrosine kinase (Btk) inhibitors and is further useful to treat inflammatory, auto immune diseases associated with aberrant B-cell proliferation such as RA (rheumatoid arthritis) and cancers. This invention also provided the preparation of a medicament using of Formula (IV), and methods of preventing or treating diseases associated with excessive Btk activity in mammals, especially humans.
    Type: Application
    Filed: November 29, 2013
    Publication date: October 22, 2015
    Inventors: Yongxin HAN, Rong YU, Zanping WANG, Zhi LIANG, Quan HU, Li ZHU, Yuandong HU, Yinghui SUN, Na ZHAO, Yong PENG, Xiaofeng ZHAI, Hong LUO, Dengming XIAO
  • KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF
    Publication number: 20140296261
    Abstract: The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.
    Type: Application
    Filed: November 14, 2012
    Publication date: October 2, 2014
    Applicants: CENTAURUS BIOPHARMA CO., LTD., CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD,
    Inventors: Dengming Xiao, Jijun Li, Yan Zhu, Yuandong Hu, Huting Wang, Zhe Wang, Zanping Wang, Yongheng Wei, Yinghui Sun, Qiong Wu, Hui Zhang, Yong Peng, Fansheng Kong, Ying Sun, Hong Luo, Yongxin Han
  • BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS
    Publication number: 20140018380
    Abstract: The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula I, pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.
    Type: Application
    Filed: January 31, 2012
    Publication date: January 16, 2014
    Applicant: CENTAURUS BIOPHARMA CO., LTD.
    Inventors: Dengming Xiao, Yan Zhu, Yuandong Hu, Huting Wang, Yuliang Liu, Jijun Li, Deguang Sun, Zhe Wang, Yongheng Wei, Zanping Wang, Guojing Tang, Lutao Jing