Patents by Inventor Zaoli Jiang
Zaoli Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240075092Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: August 21, 2023Publication date: March 7, 2024Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Patent number: 11839639Abstract: In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis (:F3), Rheum palmatum L. (:B6), Stephania tetrandra (:C4), Phellodendron chinense Schneid. (:D8), Euphorbia humifusa (:S6), Eclipta prostrata (:I2), A. venetum L. (:F1), Portulaca oleracea L. (:F5), and Sanguisorba officinalis L. (:E5), Camellia sinensis var. assamica (Mast.) Kitamura (:PE) and Punica granatum. (:PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.Type: GrantFiled: October 18, 2018Date of Patent: December 12, 2023Assignee: YALE UNIVERSITYInventors: Yung-Chi Cheng, Wing Lam, Zaoli Jiang
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Patent number: 11771731Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: GrantFiled: April 6, 2022Date of Patent: October 3, 2023Assignee: YALE UNIVERSITYInventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20220395550Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: April 6, 2022Publication date: December 15, 2022Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Patent number: 11324793Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: GrantFiled: April 14, 2020Date of Patent: May 10, 2022Assignee: YALE UNIVERSITYInventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20210196779Abstract: The invention relates in one aspect to the unexpected discovery that herbal extracts of the Rubia cordifolia plant are potent inhibitors of a range of receptors, proteins and enzymes implicated in the pathology of a number of common diseases and disorders. In certain embodiments, the method is useful for treating at least one disease or disorder related to a steroid hormone receptor including prostate cancer, breast cancer, ovarian cancer, lung cancer, leukemia and lymphoma. In other embodiments, the method is useful for treating at least one disease or disorder related to the expression of at least one protein selected from the group consisting of Brd4, Brd2, cyclin D1, p53, Gata3 and CD47.Type: ApplicationFiled: May 30, 2019Publication date: July 1, 2021Inventors: YungChi Cheng, Wing Lam, Zaoli Jiang
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Publication number: 20200376067Abstract: In one embodiment, the present invention is directed to a composition comprising an aqueous or ethanolic extract of at least one herb selected from the group consisting of Aloe barbadensis (:F3), Rheum palmatum L. (:B6), Stephania tetrandra (:C4), Phellodendron chinense Schneid. (:D8), Euphorbia humifusa (:S6), Eclipta prostrata (:I2), A. venetum L. (:F1), Portulaca oleracea L. (:F5), and Sanguisorba officinalis L. (:E5), Camellia sinensis var. assamica (Mast.) Kitamura (:PE) and Punica granatum. (:PG), and mixtures thereof. The composition is administered to a patient, in an effective amount, in a method of treating, inhibiting, preventing, reducing the incidence of, ameliorating or resolving a disease state or condition caused in part or exacerbated by hyperactivity of the androgen receptor (AR), by inhibiting the androgen receptor protein. These compositions may also be used inhibit or stabilize hair loss or grow hair in a subject in need.Type: ApplicationFiled: October 18, 2018Publication date: December 3, 2020Inventors: Yung-Chi CHENG, WING LAM, ZAOLI JIANG
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Publication number: 20200306331Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: April 14, 2020Publication date: October 1, 2020Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Patent number: 10646530Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: GrantFiled: July 30, 2018Date of Patent: May 12, 2020Assignee: YALE UNIVERSITYInventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20190117719Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: July 30, 2018Publication date: April 25, 2019Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Patent number: 10058580Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: GrantFiled: December 23, 2014Date of Patent: August 28, 2018Assignee: YALE UNIVERSITYInventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20150110906Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: December 23, 2014Publication date: April 23, 2015Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Patent number: 8871279Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer by administering the herbal composition PHY906 in combination with one or more chemotherapeutic compounds to a mammal undergoing such chemotherapy.Type: GrantFiled: June 10, 2009Date of Patent: October 28, 2014Assignee: Yale UniversityInventors: Yung-Chi Cheng, Shwu-Huey Liu, Zaoli Jiang, Robert Tilton
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Patent number: 8309141Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: GrantFiled: February 14, 2008Date of Patent: November 13, 2012Assignee: Yale UniversityInventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20120009282Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of cancer by administering the herbal composition PHY906 in combination with one or more chemotherapeutic compounds to a mammal undergoing such chemotherapy.Type: ApplicationFiled: June 10, 2009Publication date: January 12, 2012Applicants: PHYTOCEUTICA, INC., YALE UNIVERSITYInventors: Yung-Chi Cheng, Shwu-Huey Liu, Zaoli Jiang, Robert Tilton
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Publication number: 20100255129Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: February 14, 2008Publication date: October 7, 2010Applicants: YALE UNIVERSITY, PHYTOCEUTICA, INC.Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng
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Publication number: 20100166892Abstract: This invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a mammal undergoing such chemotherapy.Type: ApplicationFiled: February 14, 2008Publication date: July 1, 2010Applicants: YALE UNIVERSITY, PHYTOCEUTICA, INC.Inventors: Shwu-Huey Liu, Zaoli Jiang, Yung-Chi Cheng