Patents by Inventor Zara Melkoumian

Zara Melkoumian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
    Patent number: 8530236
    Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: September 10, 2013
    Assignee: Corning Incorporated
    Inventors: Andrei Gennadyevich Fadeev, Arthur Winston Martin, Zara Melkoumian, Christopher Bankole Shogbon, David Michael Weber, Jennifer Lynn Weber, Yue Zhou
  • SWELLABLE (METH)ACRYLATE SURFACES FOR CULTURING CELLS IN CHEMICALLY DEFINED MEDIA
    Publication number: 20130203165
    Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
    Type: Application
    Filed: November 5, 2012
    Publication date: August 8, 2013
    Inventors: Andrei Gennadyevich Fadeev, Arthur Winston Martin, Zara Melkoumian, Christopher Bankole Shogbon, David Michael Weber, Jennifer Lynn Weber, Yue Zhou
  • Synthetic surfaces for culturing cells in chemically defined media
    Patent number: 8354274
    Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: January 15, 2013
    Assignee: Geron Corporation
    Inventors: Andrei Gennadyevich Fadeev, Jennifer Gehman, Zara Melkoumian, David Michael Weber, Yue Zhou
  • Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
    Patent number: 8329469
    Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: December 11, 2012
    Assignee: Geron Corporation
    Inventors: Andrei G. Fadeev, Jennifer Gehman, Arthur Winston Martin, Zara Melkoumian, Christopher B. Shogbon, David Michael Weber, Yue Zhou
  • Cell culture article and screening
    Patent number: 8168433
    Abstract: A method for producing a cell culture article having a synthetic polymer layer for incubating with cells includes diluting one or more (meth)acrylate monomers in a solvent and dispersing the diluted monomers on a surface of the cell culture article. Some or substantially all of the solvent is removed and the monomers are then polymerized on the surface of the article to form the synthetic polymer layer attached to the surface of the article.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: May 1, 2012
    Assignee: Corning Incorporated
    Inventors: Jennifer Gehman, Arthur W. Martin, Zara Melkoumian, Christopher B. Shogbon, David M. Weber, Yue Zhou
  • Synthetic Surfaces for Differentiating Stem Cells into Cardiomyocytes
    Publication number: 20100248366
    Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.
    Type: Application
    Filed: February 8, 2010
    Publication date: September 30, 2010
    Inventors: Andrei Gennadyevich Fadeev, Jennifer Weber, Zara Melkoumian, David Michael Weber, Yue Zhou, Ralph Brandenberger
  • CELL CULTURE ARTICLE AND SCREENING
    Publication number: 20090203065
    Abstract: A method for producing a cell culture article having a synthetic polymer layer for incubating with cells includes diluting one or more (meth)acrylate monomers in a solvent and dispersing the diluted monomers on a surface of the cell culture article. Some or substantially all of the solvent is removed and the monomers are then polymerized on the surface of the article to form the synthetic polymer layer attached to the surface of the article.
    Type: Application
    Filed: January 30, 2009
    Publication date: August 13, 2009
    Inventors: JENNIFER GEHMAN, ARTHUR W. MARTIN, ZARA MELKOUMIAN, CHRISTOPHER B. SHOGBON, DAVID M. WEBER, YUE ZHOU
  • SYNTHETIC SURFACES FOR CULTURING CELLS IN CHEMICALLY DEFINED MEDIA
    Publication number: 20090191627
    Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.
    Type: Application
    Filed: January 30, 2009
    Publication date: July 30, 2009
    Inventors: Andrei Gennadyevich Fadeev, Jennifer Gehman, Zara Melkoumian, David Michael Weber, Yue Zhou
  • (METH)ACRYLATE SURFACES FOR CELL CULTURE, METHODS OF MAKING AND USING THE SURFACES
    Publication number: 20090191634
    Abstract: A synthetic cell culture surface, prepared from a polymerized blend of at least two (meth)acrylate monomers is provided, which supports the growth of undifferentiated human embryonic stem cells in defined media augmented with fetal bovine serum. The cell culture surface forms a uniform layer over the growth area of a typical cell culture vessel.
    Type: Application
    Filed: January 30, 2009
    Publication date: July 30, 2009
    Inventors: Arthur W Martin, Zara Melkoumian, Christopher B. Shogbon, Yue Zhou
  • SWELLABLE (METH)ACRYLATE SURFACES FOR CULTURING CELLS IN CHEMICALLY DEFINED MEDIA
    Publication number: 20090191632
    Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.
    Type: Application
    Filed: January 30, 2009
    Publication date: July 30, 2009
    Inventors: Andrei G. Fadeev, Jennifer Gehman, Arthur Winston Martin, Zara Melkoumian, Christopher B. Shogbon, David Michael Weber, Yue Zhou