Patents by Inventor Zaruhi Hovhannisyan

Zaruhi Hovhannisyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • loss of function rodent model
    Patent number: 11825819
    Abstract: This disclosure relates to a genetically modified rodent and use thereof as a rodent model. More specifically, this disclosure relates to rodent (e.g., mouse or rat) comprising a loss of function mutation in an endogenous Crnn (cornulin) gene, and to use of such a rodent animal as a rodent model of skin inflammation disorders (e.g., psoriasis).
    Type: Grant
    Filed: October 2, 2020
    Date of Patent: November 28, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Claudia Gonzaga-Jauregui, Sokol Haxhinasto, Zaruhi Hovhannisyan, Kavita Praveen
  • MOUSE MODEL OF DITRA DISEASE AND USES THEREOF
    Publication number: 20230172172
    Abstract: This disclosure relates to genetically modified rodent animals and rodent models of human diseases. More specifically, this disclosure relates to genetically modified rodents whose genome comprises a humanized Il1rl2 gene (coding for the IL1rl2 subunit of the IL-36R protein) and human IL-36?, ? and ? ligand genes. The genetically modified rodents disclosed herein display enhanced skin and intestinal inflammation as a preclinical model of psoriasis and IBD, respectively, and serve as a rodent model of human DITRA disease.
    Type: Application
    Filed: January 25, 2023
    Publication date: June 8, 2023
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Andrew J. Murphy, Alexander O. Mujica, Ka-Man Venus Lai, Sokol Haxhinasto, Zaruhi Hovhannisyan
  • CRNN LOSS OF FUNCTION RODENT MODEL
    Publication number: 20210100227
    Abstract: This disclosure relates to a genetically modified rodent and use thereof as a rodent model. More specifically, this disclosure relates to rodent (e.g., mouse or rat) comprising a loss of function mutation in an endogenous Crnn (cornulin) gene, and to use of such a rodent animal as a rodent model of skin inflammation disorders (e.g.
    Type: Application
    Filed: October 2, 2020
    Publication date: April 8, 2021
    Inventors: Claudia GONZAGA-JAUREGUI, Sokol HAXHINASTO, Zaruhi HOVHANNISYAN
  • NON-HUMAN ANIMAL MODELS OF DITRA DISEASE AND USES THEREOF
    Publication number: 20200015462
    Abstract: This disclosure relates to genetically modified rodent animals and rodent models of human diseases. More specifically, this disclosure relates to genetically modified rodents whose genome comprises a humanized Il1rl2 gene (coding for the IL1rl2 subunit of the IL-36R protein) and human IL-36?, ? and ? ligand genes. The genetically modified rodents disclosed herein display enhanced skin and intestinal inflammation as a preclinical model of psoriasis and IBD, respectively, and serve as a rodent model of human DITRA disease.
    Type: Application
    Filed: July 16, 2019
    Publication date: January 16, 2020
    Inventors: Andrew J. Murphy, Alexander O. Mujica, Ka-Man Venus Lai, Sokol Haxhinasto, Zaruhi Hovhannisyan