Patents by Inventor Zaverio Ruggeri

Zaverio Ruggeri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ANTI-THROMBOTIC AND HEMOSTATIC THERAPIES
    Publication number: 20210395341
    Abstract: In various embodiments, disclosed herein are methods of assessing therapeutic efficacy of an anticoagulant. Preferably, the method comprising providing a blood sample; perfusing the blood sample over a surface coated with collagen or immobilized rTF; measuring platelet aggregation and fibrin deposition on the surface coated with collagen or immobilized rTF; and assessing therapeutic efficacy of the anticoagulant based on the volume of platelet aggregates and/or deposited fibrin.
    Type: Application
    Filed: August 27, 2021
    Publication date: December 23, 2021
    Applicant: The Scripps Research Institute
    Inventors: Zaverio Ruggeri, Wolfram Ruf, Yuichi Kamikubo
  • Compositions and methods for thrombin generation assay
    Patent number: 11136370
    Abstract: In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF, FIXa, and CaCl2; and measuring TG in the blood sample. Also disclosed herein are assays for determining a bleeding risk in a subject, comprising obtaining a blood sample from the subject; adding to the blood sample TF and/or FIXa; determining the amount of coagulation factor VIII (FVIII:C) in the blood sample; and determining (a) a mild bleeding risk in the subject if the amount of FVIII:C in the sample is >5 IU/dL, (b) a moderate bleeding risk in the subject if the amount of FVIII:C in the sample is 1-5 IU/dL, and (c) a severe bleeding risk in the subject if the amount of FVIII:C in the subject is <1 IU/dL.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: October 5, 2021
    Assignee: The Scripps Research Institute
    Inventors: Zaverio Ruggeri, Wolfram Ruf, Yuichi Kamikubo
  • COMPOSITIONS AND METHODS FOR ANTI-THROMBOTIC AND HEMOSTATIC THERAPIES
    Publication number: 20190127442
    Abstract: In various embodiments, disclosed herein are assays for measuring thrombin generated (TG) in a blood sample, comprising: incubating the blood sample with TF, FIXa, and CaCl2; and measuring TG in the blood sample. Also disclosed herein are assays for determining a bleeding risk in a subject, comprising obtaining a blood sample from the subject; adding to the blood sample TF and/or FIXa; determining the amount of coagulation factor VIII (FVIII:C) in the blood sample; and determining (a) a mild bleeding risk in the subject if the amount of FVIII:C in the sample is >5 IU/dL, (b) a moderate bleeding risk in the subject if the amount of FVIII:C in the sample is 1-5 IU/dL, and (c) a severe bleeding risk in the subject if the amount of FVIII:C in the subject is <1 IU/dL.
    Type: Application
    Filed: May 12, 2017
    Publication date: May 2, 2019
    Inventors: Zaverio Ruggeri, Wolfram Ruf, Yuichi Kamikubo