Patents by Inventor Zbigniew Matusiak

Zbigniew Matusiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indolylalkylamino-methylidenecarbamate derivatives useful as GnRH antagonists
    Patent number: 7449489
    Abstract: The invention relates to a group of novel indole compounds of Formula (I): wherein: R1, R2, R4, R6, R6a, R7, R8, R9, R10, and A are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: November 11, 2008
    Assignee: AstraZeneca AB
    Inventors: Francis Thomas Boyle, Robert Davies, Zbigniew Matusiak, Michael Wardleworth
  • 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
    Publication number: 20080045517
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: May 22, 2007
    Publication date: February 21, 2008
    Applicant: AstraZeneca AB
    Inventors: Kevin Foote, Zbigniew Matusiak, Alexander Dossetter, Jean Claude Arnould, Maryannick Lamorlette, Benedicte Delouvrie, Annie Hamon
  • 6H-THIENO [2,3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)
    Patent number: 7268158
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: September 11, 2007
    Assignee: AstraZeneca AB
    Inventors: Kevin Michael Foote, Zbigniew Matusiak, Alexander Graham Dossetter, Jean Claude Arnould, Maryannick Andree Lamorlette, Benedicte Delouvrie, Annie Hamon
  • Derivatives of thienopyrrole as gnrh antagonists
    Publication number: 20070185185
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I) wherein: R1, R2, R3, R4 are as defined in the specification, which compounds are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: February 17, 2005
    Publication date: August 9, 2007
    Applicant: ASTRAZENECA AB
    Inventors: David Andrews, Zbigniew Matusiak
  • Indolylalkylamino-methylidenecarbamate derivatives useful as gnrh antagonists
    Publication number: 20060258710
    Abstract: The invention relates to a group of novel indole compounds of Formula (I): wherein: R1, R2, R4, R6, R6a, R7, R8, R9, R10, and A are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: August 18, 2003
    Publication date: November 16, 2006
    Inventors: Francis Boyle, Robert Davies, Zbigniew Matusiak, Michael Wardleworth
  • 6H-thieno[2, 3-b]pyrrole derivatives as antagonists of gonadotropin releasing hormone (GnRH)
    Patent number: 7132442
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: November 7, 2006
    Assignee: AstraZeneca AB
    Inventors: Kevin Michael Foote, Zbigniew Matusiak, Alexander Graham Dossetter, Jean Claude Arnould, Maryannick Andree Lamorlette, Benedicte Delouvrie, Annie Hamon
  • 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
    Publication number: 20060235067
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: May 1, 2006
    Publication date: October 19, 2006
    Applicant: AstraZeneca AB
    Inventors: Kevin Foote, Zbigniew Matusiak, Alexander Dossetter, Jean Claude Arnould, Maryannick Lamorlette, Benedicte Delouvrie, Annie Hamon
  • Farnesyl transferase inhibitors
    Patent number: 7101897
    Abstract: This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: September 5, 2006
    Assignee: AstraZeneca AB
    Inventors: James Michael Wardleworth, Francis Thomas Boyle, Zbigniew Matusiak
  • 6H-thieno'2, 3-b!pyrrole derivatives as antagonists of gonadotropin releasing hormone (gnrh)
    Publication number: 20060004082
    Abstract: The invention relates to a group of novel thieno-pyrrole compounds of Formula (1): wherein: R1, R2, R3, R4 and R5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.
    Type: Application
    Filed: August 19, 2003
    Publication date: January 5, 2006
    Applicant: AstraZeneca
    Inventors: Kevin Foote, Zbigniew Matusiak, Alexander Dossetter, Jean Arnould, Maryannick Lamorlette, Benedicte Delouvrie, Annie Hamon
  • Inhibitors of farnesyl protein transferase
    Patent number: 6777438
    Abstract: This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: August 17, 2004
    Assignee: AstraZeneca AB
    Inventors: James Michael Wardleworth, Francis Thomas Boyle, Zbigniew Matusiak
  • Inhibitors of farnesyl protein transferase
    Publication number: 20030096842
    Abstract: This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
    Type: Application
    Filed: June 20, 2002
    Publication date: May 22, 2003
    Inventors: James Michael Wardleworth, Francis Thomas Boyle, Zbigniew Matusiak
  • Farnesyl transferase inhibitors
    Publication number: 20030083348
    Abstract: 1 This invention relates to compounds of formula (1) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation.
    Type: Application
    Filed: April 17, 2002
    Publication date: May 1, 2003
    Inventors: James Michael Wardleworth, Francis Thomas Boyle, Zbigniew Matusiak