Abstract: Non-occlusive composite wound dressings that comprises a material polymer wound-healing layer comprised of isolated polymer fibers, and a synthetic polymer foam layer having at least one surface physically adhered to the natural layer by the physical interlocking of the polymer fibers with the surface. Also, a process for the preparation of a non-occlusive composite wound dressing comprising contacting a synthetic polymer foam porous surface with a solution and/or suspension of natural polymer fibers in a medium, and removing the medium from the fibers under conditions that result in the fibers penetrating into pores of the surface and that form a dried composite of the polymer foam adhered physically to a layer comprising natural polymer fiber.

Abstract: A multilayer material with improved mechanical, physical, functional and handling properties for use in human and veterinary medicine for reconstruction of tissue or organs comprises at least two layers of a reconstituted natural polymer matrix, preferentially collagen, and optionally one or more layers comprising a biocompatible synthetic polymer which may be bioinert or biodegradable. The multilayer construct is prepared by simultaneously applying elevated heat and pressure to the combined layers for a short period of time sufficient to bond said layers but insufficient to denature said natural polymer. The materials of the layers may optionally contain biologically active substances or substances which improve mechanical, functional, biological and/or handling properties of the material.

Abstract: The invention is concerned with relatively dense and fluid expandable natural polymer-based membrane, preferably collagen-based material, with improved mechanical, physical, functional, and handling properties for use in human and veterinary medicinal applications. The membranous material is preferably collagen, and optionally contains additional biologically active substances such as hemostatic agents, growth factors, cytokines, hormones, drugs and the like, and/or biologically important and tissue-compatible inorganic or/and organic substances or/and their derivatives which can improve the mechanical, functional and handling properties of the material. The membrane is obtainable by simultaneous heat and pressure treatment of a basic natural polymer material for short periods of time.

Abstract: Non-occlusive composite wound dressing are disclosed that comprise a natural polymer wound-healing layer comprised of isolated polymer fibers, and a synthetic polymer foam layer having at least one surface physically adhered to said natural layer by the physical interlocking of said polymer fibers with said surface. Also disclosed is a process for the preparation of a non-occlusive composite wound dressing comprising contacting a synthetic polymer foam porous surface with a solution and/or suspension of natural polymer fibers in a medium, and removing said medium from said fibers under conditions that result in said fibers penetrating into pores of said surface and that form a dried composite of said synthetic polymer foam adhered physically to a layer comprising natural polymer fiber.