Patents by Inventor Zbigniew S. Zelawski

Zbigniew S. Zelawski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical synthesis of flavipucine
    Patent number: 4094878
    Abstract: A method for the total chemical synthesis of flavipucine employs the condensation of 4-hydroxy-6-methyl-2-pyridone with isobutylglyoxal in alkali alkoxide. The resulting alkali salt is acylated in both the 1' and 4 positions. Treatment of the 1',4-diacyloxy derivative with excess alkaline peroxide yields flavipucine.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: June 13, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, Narindar N. Girotra, Zbigniew S. Zelawski, deceased
  • 3.beta.-[(Methoxalyl)oxy]-2.alpha.-(3-oxo-1-octeny l)-5-oxo-1.beta.-cyclopentaneheptanoic acid and process
    Patent number: 4005106
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoetyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneh eptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 7, 1975
    Date of Patent: January 25, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • 2.alpha.-(2-Carboxy-2-formylethyl )-3.beta.-hydroxy-5-oxo-.beta.-cyclopentaneheptanoic acid and process
    Patent number: 3998849
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentane heptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: December 21, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • 2.alpha.-Formyl-3.beta.-[(methoxalyl)oxy]-5-oxo-1.beta.-cyclopentanehepta noic acid and process
    Patent number: 3992411
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha., 6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentane heptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: November 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • 2.alpha.-(2-Carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-c yclopentaneheptanoic acid and process
    Patent number: 3992412
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha., 6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentane heptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: November 16, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • 2.alpha.-(2-Loweralkanoyloxy-2-carboxyvinyl)-3.beta.-hydroxy-5-oxo-1.beta.- c
    Patent number: 3991083
    Abstract: Racemic or optically-active prostaglandin E.sub.1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3.alpha.,6,7,7.alpha.-tetrahydro-4-methyl-2-oxo-1.beta.-indaneheptanoic acid methyl ester proceeding through 2.alpha.-(2-carboxyethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentaneheptan oic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-formylethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopent aneheptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, 2.alpha.-(2-carboxy-2-oxoethyl)-3.beta.-hydroxy-5-oxo-1.beta.-cyclopentane heptanoic acid methyl ester, .delta.-lactone, 5-cyclic ethylene acetal, and 3.beta.-hydroxy-2.alpha.-(3-oxo-1-octenyl)-5-oxo-1.beta.-cyclopentanehepta noic acid methyl ester, 5-cyclic ethylene acetal.
    Type: Grant
    Filed: May 8, 1975
    Date of Patent: November 9, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Norman L. Wendler, David Taub, Harry L. Slates, Zbigniew S. Zelawski
  • Precursors for prostaglandin E.sub.1
    Patent number: 3978115
    Abstract: The disclosure relates to novel precursors for the synthesis of prostaglandin E.sub.1 and the production of said precursors.
    Type: Grant
    Filed: May 14, 1975
    Date of Patent: August 31, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Zbigniew S. Zelawski, Norman L. Wendler
  • Precursors for prostaglandin E.sub.1
    Patent number: 3933901
    Abstract: This case relates to the synthesis of novel precursors of prostaglandin E.sub.1, particularly the intermediate 4-hydroxy-3 .alpha.-methyl-1.alpha., 2.alpha.-dilower-alkanoyloxymethylcyclohexene.
    Type: Grant
    Filed: May 2, 1973
    Date of Patent: January 20, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Zbigniew S. Zelawski, Norman L. Wendler