Patents by Inventor Zdenek Holan

Zdenek Holan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformation-activity relationship of apoptosis-inducing phosphodiester oligonucleotides
    Publication number: 20080077372
    Abstract: The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.
    Type: Application
    Filed: February 9, 2007
    Publication date: March 27, 2008
    Inventors: Nigel Phillips, Mario Filion, Zdenek Holan, Stephanie Reader