Patents by Inventor Zdenek Hostomsky

Zdenek Hostomsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti Notch-1 antibodies
    Patent number: 9090690
    Abstract: This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: July 28, 2015
    Assignee: Pfizer Inc.
    Inventors: Kang Li, Ping Wei, Qinghai Peng, John Andrew Lippincott, Donna Marie Stone, Zdenek Hostomsky
  • ANTI NOTCH-1 ANTIBODIES
    Publication number: 20120093813
    Abstract: This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.
    Type: Application
    Filed: June 16, 2010
    Publication date: April 19, 2012
    Applicant: PFIZER INC
    Inventors: Kang Li, Ping Wei, Qinghai Peng, John Andrew Lippincott, Donna Marie Stone, Zdenek Hostomsky
  • Therapeutic combinations comprising poly (ADP-ribose) polymerases inhibitor
    Publication number: 20060074073
    Abstract: This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.
    Type: Application
    Filed: September 20, 2005
    Publication date: April 6, 2006
    Inventors: Heidi Marie Steinfeldt, Theodore James Boritzki, Alan Hilary Calvert, Nicola Jane Curtin, Mohamed Raza Dewji, Zdenek Hostomsky, Christopher Jones, Rhonda Kaufman, Karen Klamerus, David Richard Newell, Elizabeth Ruth Plummer, Steven Reich, Ian Stratford, Huw David Thomas, Kay Janine Williams