Patents by Inventor Zdenek Richard Holan

Zdenek Richard Holan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial Ribonucleic Acid Cell Wall Compositions and Methods of Making and Using Them
    Publication number: 20160151475
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Application
    Filed: November 30, 2015
    Publication date: June 2, 2016
    Applicant: Telesta Therapeutics IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Bacterial ribonucleic acid cell wall compositions and methods of making and using them
    Patent number: 9220765
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: December 29, 2015
    Assignee: BIONICHE UROLOGY IP INC.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Bacterial ribonucleic acid cell wall compositions and methods of making and using them
    Patent number: 9180177
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: November 10, 2015
    Assignee: Bioniche Urology IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mohamed Elrafih
  • Bacterial ribonucleic acid cell wall compositions and methods of making and using them
    Patent number: 9138469
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: September 22, 2015
    Assignee: Bioniche Urology IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mohamed Elrafih
  • BACTERIAL RIBONUCLEIC ACID CELL WALL COMPOSITIONS AND METHODS OF MAKING AND USING THEM
    Publication number: 20150224183
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Application
    Filed: April 27, 2015
    Publication date: August 13, 2015
    Applicant: Bioniche Urology IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Bacterial ribonucleic acid cell wall compositions and methods of making and using them
    Patent number: 9044422
    Abstract: The present invention relates to novel mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity. The present invention also relates to a synthetic medium for the cultivation of mycobacteria.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: June 2, 2015
    Assignee: BIONICHE UROLOGY IP INC.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Bacterial Ribonucleic Acid Cell Wall Compositions and Methods of Making and Using Them
    Publication number: 20140322372
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Application
    Filed: February 25, 2014
    Publication date: October 30, 2014
    Applicant: BIONICHE UROLOGY IP INC.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Bacterial Ribonucleic Acid Cell Wall Compositions and Methods of Making and Using Them
    Publication number: 20140170189
    Abstract: The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 19, 2014
    Applicant: Bioniche Urology IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • BACTERIAL RIBONUCLEIC ACID CELL WALL COMPOSITIONS AND METHODS OF MAKING AND USING THEM
    Publication number: 20130142828
    Abstract: The present invention relates to novel mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune stimulating and anti-cancer activity. The present invention also relates to a synthetic medium for the cultivation of mycobacteria.
    Type: Application
    Filed: October 13, 2011
    Publication date: June 6, 2013
    Applicant: Bioniche Urology IP Inc.
    Inventors: Nigel C. Phillips, Danbing Ke, Zdenek Richard Holan, Mario C. Filion, Mohamed Elrafih, Iqubal Velji
  • Oligonucleotide compositions and their use to induce apoptosis
    Patent number: 8350016
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: January 8, 2013
    Assignee: Bioniche Life Sciences Inc.
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stephanie Reader
  • Oligonucleotide Compositions and Their Use to Induce Apoptosis
    Publication number: 20110160291
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Application
    Filed: February 7, 2011
    Publication date: June 30, 2011
    Applicant: Bioniche Life Sciences Inc.
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stephanie Reader
  • Oligonucleotide compositions and their use to induce apoptosis
    Patent number: 7893242
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: February 22, 2011
    Assignee: Bioniche Life Sciences Inc.
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stephanie Reader
  • Oligonucleotide Compositions and Their Use to Induce Apoptosis
    Publication number: 20080081793
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Application
    Filed: January 24, 2007
    Publication date: April 3, 2008
    Applicant: BIONICHE LIFE SCIENCES, INC.
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stephanie Reader
  • Conformation-activity relationship of apoptosis-inducing phosphodiester oligonucleotides
    Patent number: 7200531
    Abstract: The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: April 3, 2007
    Assignee: Bionicrie Life Sciences, Inc.
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stéphanie Reader
  • Oligonucleotide compositions and their use to induce apoptosis
    Patent number: 7199228
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: April 3, 2007
    Assignee: Bioniche Life Sciences, Inc
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan, Stéphanie Reader
  • Conformation-activity relationship of apoptosis-inducing phosphodiester oligonucleotides
    Publication number: 20030144233
    Abstract: The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and charge characteristics of the oligonucleotides. Biological activities include, but are not limited to, cellular proliferation, induction of cell cycle arrest and apoptosis.
    Type: Application
    Filed: August 19, 2002
    Publication date: July 31, 2003
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan
  • Oligonucleotide compositions and their use to induce apoptosis
    Publication number: 20030113763
    Abstract: The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These sequences optionally further comprise one or more guanine bases or one or more thymine bases, or combinations thereof. The present invention also provides methods of using these compositions to induce responses in cells, and to treat diseases and conditions characterized by undesired cellular proliferation such as autoimmune disease, lymphoproliferative disease, inflammation or cancer.
    Type: Application
    Filed: August 19, 2002
    Publication date: June 19, 2003
    Inventors: Nigel C. Phillips, Mario C. Filion, Zdenek Richard Holan