Patents by Inventor Zdenek Roubal

Zdenek Roubal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-(2-(2-benzimidazolyl) benzolyloxyethyl)-4(3H)-quinazolinone
    Patent number: 4599415
    Abstract: This invention relates to the compound 3-[2-(2-Benzimidazolyl) Benzoyloxyethyl]-4(3H)-Quinazolinone of Formula I, and a process for the preparation thereof. The compound exhibits strong analgesic activity and almost zero toxicity in laboratory mice. ##STR1## The compound of Formula I is prepared by acylation of the compound 3-(2-hydroxyethyl)-4(3H)-quinazolinone with a reactive derivative of 2-(2-benzimidazolyl)benzoic acid, preferably its imidazolide, formed by treatment of the acid of Formula III with 1,1'-carbonyldiimidazole. The compounds of Formula II and Formula III are reacted in situ, at room temperature, and in the presence of an inert organic solvent. The product compound is isolated and purified by common techniques.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: July 8, 1986
    Assignee: SPOFA, spojene podniky pro zdravotnickou vyrobu
    Inventors: Ludmila Fisnerova, Jaroslava Grimova, Zdenek Roubal, Oldrich Nemecek
  • 2-Phenyl-2-carboxyethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate and process for preparation thereof
    Patent number: 4136194
    Abstract: A technique is described for the preparation of a novel anti-inflammatory agent comprising 2-phenyl-2-carboxyethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate. The preparative technique involves reacting indomethacin with tropic acid.
    Type: Grant
    Filed: June 30, 1977
    Date of Patent: January 23, 1979
    Assignee: SPOFA, United Pharmaceutical Works
    Inventors: Ludmila Fisnerova, Jaroslava Grimova, Zdenek Roubal, Oldrich Nemecek