Patents by Inventor Zdenek Valenta

Zdenek Valenta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridones and their use as modulators of serine hydrolase enzymes
    Patent number: 6544986
    Abstract: This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C═O or CH2; and R7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl (C6-C14)aryl; or R7 and R8 when taken together form a (C2-C7)alkylene group; or —NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: April 8, 2003
    Assignee: Dalhousie University
    Inventors: Sultan Darvesh, David Magee, Zdenek Valenta, Earl Martin
  • Pyridones and their use as modulators of serine hydrolase enzymes
    Patent number: 6436972
    Abstract: This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C═O or CH2; and R7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl(C6-C14)aryl; or R7 and R8 when taken together form a (C2-C7)alkylene group; or —NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: August 20, 2002
    Assignee: Dalhousie University
    Inventors: Sultan Darvesh, David Magee, Zdenek Valenta, Earl Martin
  • Novel pyridones and their use as modulators of serine hydrolase enzymes
    Publication number: 20020049330
    Abstract: This invention relates to a compound of formula I: 1
    Type: Application
    Filed: October 9, 2001
    Publication date: April 25, 2002
    Applicant: Dalhousie University
    Inventors: Sultan Darvesh, David Magee, Zdenek Valenta, Earl Martin
  • 14.beta.-Hydroxyandrostanes
    Patent number: 4201717
    Abstract: 14.beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11)-androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: May 6, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Zdenek Valenta
  • 14.beta.-Hydroxyandrostanes
    Patent number: 4199530
    Abstract: 14.beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11) -androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: April 22, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Zdenek Valenta
  • 14 .beta.-Hydroxyandrostanes
    Patent number: 4193940
    Abstract: 14.beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11)-androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: March 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Zdenek Valenta
  • 14.beta.-Hydroxyandrostanes
    Patent number: 4193878
    Abstract: 14 .beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11)-androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: March 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Zdenek Valenta
  • 14.beta.-Hydroxyandrostanes
    Patent number: 4134920
    Abstract: 14.beta.-Hydroxyandrostanes and processes for the preparation thereof in which the 14.beta.-hydroxy group is fabricated internally by means of a novel cyclization of 8,14-seco-4,6,9(11)-androstatrien-3,14,17-triones is disclosed.The 14.beta.-hydroxyandrostanes are useful as precursors for the synthesis of cardenolides and related products.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: January 16, 1979
    Inventor: Zdenek Valenta