Patents by Inventor Ze?apos;ev A. Ronai

Ze?apos;ev A. Ronai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020169121
    Abstract: The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies such as radiation, chemotherapy, or combinations of both approaches. The invention provides methods for identifying and implementing strategies to inhibit a transcription factor which, in combination with other factors, renders the cells resistant and inhibits apopotosis of the cells. The invention provides an inhibitory ATF2 N-terminal fragment, specifically a fragment corresponding to amino acid residues 50-100 of ATF2 (termed peptide II). The invention provides methods for inhibiting tumor cell growth with such peptides.
    Type: Application
    Filed: February 14, 2002
    Publication date: November 14, 2002
    Applicant: Mount Sinai School of Medicine
    Inventor: Ze?apos;ev Ronai
  • Publication number: 20020031818
    Abstract: The present invention discloses a method for modulating Mdm2 activity by altering the level of sumoylation and ubiquitination of the Mdm2 protein, which in turn may modulate p53 activity. The invention further provides methods of detecting sumoylation of Mdm2, an assay system for identifying a test compound that regulates sumoylation of Mdm2, and a method of treating a condition of uncontrolled cell growth.
    Type: Application
    Filed: June 22, 2001
    Publication date: March 14, 2002
    Inventors: Ze?apos;ev A. Ronai, Serge Y. Fuchs