Abstract: The present invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access luminal spaces within the body of a patient without sacrificing the quality of optical data obtained. The accessory device further comprises either, singly, or in combination, selectable features or options which optimize light transmission, maximize patient comfort, and provide single-use capabilities.

Abstract: The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signal from the sample. Methods and systems of the invention also comprise monitoring an optical signal from an endogenous chromophore upon application of a chemical agent to a sample. Methods and systems of the invention also comprise the use of triggers, atomizers and image alignment to enhance the results of methods described herein.

Abstract: The invention provides methods and systems for monitoring effects of chemical agents on optical signals produced by samples in response to the chemical agents. Preferred methods comprise application of multiple chemical agents that interact to alter an optical signal from the sample. Methods and systems of the invention also comprise monitoring an optical signal from an endogenous chromophore upon application of a chemical agent to a sample. Methods and systems of the invention also comprise the use of triggers, atomizers and image alignment to enhance the results of methods described herein.

Abstract: The present invention recognizes that optical probes function both as medical access devices and as instruments which collect complex optical data. The invention provides an optical probe accessory device which can access luminal spaces within the body of a patient without sacrificing the quality of optical data obtained. The accessory device further comprises either, singly, or in combination, selectable features or options which optimize light transmission, maximize patient comfort, and provide single-use capabilities.

Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes an optical assembly and a protective barrier. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The optical assembly can be configured as a probe, to be directed to the evaluation of a sample of a biological material.

Abstract: Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes an optical assembly and a protective barrier. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The optical assembly can be configured as a probe, to be directed to the evaluation of a sample of a biological material.