Patents by Inventor Ze Lu

Ze Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for improved deliver, expression or activity of RNA interference agents
    Patent number: 8802138
    Abstract: The present disclosure provides methods and compositions for enhanced delivery of siRNA or miRNA, into the interior of multilayered tissues, and into the cytoplasm or nucleus of cells of a tissue. Such methods and compositions yield tumor-selective and intracellular delivery of RNAi agents and allow for RNAi-mediated activity such as knock-down of the target genes and associated products. The current disclosure further provides methods and compositions for improving the intracellular bioavailability of nucleotide agents.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: August 12, 2014
    Inventors: Jessie L.-S. Au, M. Guillaume Wientjes, Ze Lu, Jie Wang
  • Methods and Compositions for Improved Deliver, Expression or Activity of RNA Interference Agents
    Publication number: 20120225115
    Abstract: The present disclosure provides methods and compositions for enhanced delivery of siRNA or miRNA, into the interior of multilayered tissues, and into the cytoplasm or nucleus of cells of a tissue. Such methods and compositions yield tumor-selective and intracellular delivery of RNAi agents and allow for RNAi-mediated activity such as knock-down of the target genes and associated products. The current disclosure further provides methods and compositions for improving the intracellular bioavailability of nucleotide agents.
    Type: Application
    Filed: April 11, 2012
    Publication date: September 6, 2012
    Inventors: Jessie L.-S. Au, M. Guillaume Wientjes, Ze Lu, Jie Wang