Abstract: The present invention relates to a method for manipulating a tiny object, including: providing a charged particle beam; forming a non-uniform charge distribution in a fluid medium; and applying, to a tiny object, a gradient force formed by the non-uniform charge distribution. The present invention extends manipulation to a nanoscale, and can be applied to various microscopic tiny objects such as conductors, non-conductors, and living or non-living biological cells or organelles, and therefore surely promote great progress in the fields of physics, chemistry, biology and medicine.

Abstract: Techniques for suppressing notifications are disclosed. An incident may repeatedly flap between various resolved and unresolved states. Furthermore, other incident attributes may flap between various states such as, for example, varying levels of incident severity. Each change in state results in the transmission of a notification. In order to reduce the number of notifications, the system estimates a flapping window for the incident based on the flapping behavior of prior incidents. The system computes a notification suppression window based at least in part on the estimated flapping window. The system suppresses notifications corresponding to changes in incident state that are detected during the notification suppression window. The notification suppression window may be extended in response to extending the estimated flapping window.

Abstract: Techniques for suppressing notifications are disclosed. An incident may repeatedly flap between various resolved and unresolved states. Furthermore, other incident attributes may flap between various states such as, for example, varying levels of incident severity. Each change in state results in the transmission of a notification. In order to reduce the number of notifications, the system estimates a flapping window for the incident based on the flapping behavior of prior incidents. The system computes a notification suppression window based at least in part on the estimated flapping window. The system suppresses notifications corresponding to changes in incident state that are detected during the notification suppression window. The notification suppression window may be extended in response to extending the estimated flapping window.

Abstract: The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

Abstract: The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

Abstract: The invention provides a method of treating cancer in a subject in need thereof, comprising administering to the subject: (a) a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or an acyl group; and (b) a PD-1 signaling inhibitor; wherein the compound of Formula I or pharmaceutically acceptable salt thereof and the PD-1 signaling inhibitor are administered in amounts which in combination are therapeutically effective. The invention further provides a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, a PD-1 signaling inhibitor and a pharmaceutically acceptable carrier or excipient.

Abstract: Methods, computer systems, and computer-storage media are provided for reference resolution. The present invention seeks to resolve entities in conversational search. To enable a more natural conversational search interaction, referential expressions such as pronouns are handled in queries. A component keeps track of previous queries and performs reference resolution based on an entity in the previous query and reformulates the query using an identifier for the referenced entity. Reference resolution may be performed for pronouns, plural pronouns, partial names, across domains, and on any device or platform.

Abstract: Methods, computer systems, and computer-storage media are provided for reference resolution. The present invention seeks to resolve entities in conversational search. To enable a more natural conversational search interaction, referential expressions such as pronouns are handled in queries. A component keeps track of previous queries and performs reference resolution based on an entity in the previous query and reformulates the query using an identifier for the referenced entity. Reference resolution may be performed for pronouns, plural pronouns, partial names, across domains, and on any device or platform.