Patents by Inventor Zea Borok

Zea Borok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lentivirus vectors for gene transfer to alveolar epithelial cells
    Patent number: 7601345
    Abstract: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: October 13, 2009
    Assignee: University of Southern California
    Inventors: Zea Borok, Nori Kasahara, Edward Crandall
  • Lentivirus vectors for gene transfer to alveolar epithelial cells
    Publication number: 20080081365
    Abstract: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.
    Type: Application
    Filed: March 9, 2007
    Publication date: April 3, 2008
    Applicant: University of Southern California
    Inventors: Zea Borok, Noriyuki Kasahara, Edward Crandall
  • Lentivirus vectors for gene transfer to alveolar epithelial cells
    Patent number: 7211247
    Abstract: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: May 1, 2007
    Assignee: University of Southern California
    Inventors: Zea Borok, Noriyuki Kasahara, Edward Crandall
  • Lentivirus vectors for gene transfer to alveolar epithelial cells
    Publication number: 20020182732
    Abstract: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention also demonstrates the successful in vivo transfer of genes through lentivirus vector transduction. Mammals injected with lentivirus vector via the trachea expressed the reporter protein in alveolar epithelial cells within 48 to 72 hours after infection.
    Type: Application
    Filed: April 9, 2002
    Publication date: December 5, 2002
    Applicant: University of Southern California
    Inventors: Zea Borok, Nori Kasahara, Edward Crandall