Abstract: A system of radio frequency communication between Readers and Tags having a scalable Media Access Control (MAC) protocol for an active RFID system employing multiple access. The system comprising at least one tag Reader and a plurality of Tags each having a unique tag ID and deployed in a region in which at least some of the Tags are in radio communication with the tag Reader. A multi-dimensional addressing scheme of the MAC protocol enables division of the plurality of Tags into a number of groups for different stages of MAC protocol processing, based on different portions of the tag ID. The MAC has an inherent flexibility in the sense that it allows readers to communicate with different versions of tags and also optimize communication parameters to reader's capabilities, without pre-configuration of the tags. Furthermore, the MAC supports means to achieve very high access reliability, such as relay between tags.