Patents by Inventor Zee-Fen CHANG

Zee-Fen CHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
    Patent number: 9662328
    Abstract: The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: May 30, 2017
    Inventors: Zee-Fen Chang, Jim-Min Fang
  • TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS
    Publication number: 20160151362
    Abstract: The present invention relates to novel TMPK inhibitor and their methods of use. In particular, it relates to novel TMPK inhibitor of Formula (I) and therapeutics that decrease the cellular dTTP level to suppress the growth and inhibit DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: Zee-Fen CHANG, Jim-Min FANG
  • Targeting human thymidylate kinase induces DNA repair toxicity in malignant tumor cells
    Patent number: 9278982
    Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: March 8, 2016
    Assignees: NATIONAL YANG-MING UNIVERSITY, NATIONAL TAIWAN UNIVERSITY
    Inventors: Zee Fen Chang, Jim-Min Fang, Chun-Mei Hu, Ming-Tyng Yeh
  • Reagents for probing ROCKs activation
    Patent number: 9017952
    Abstract: A set of agents is provided for probing/detecting the activation of Rho-associated protein kinase I and II individually encoding their amino acid sequence (SEQ ID NO:1 for ROCKI and SEQ ID NO:2 for ROCKII) in biological samples. The agents include one antibody to specifically recognize ROCKI Ser1333 phosphorylation and one antibody to specifically recognize ROCKII Ser1366 phosphorylation. The agents can be used for pathological analysis in cardiovascular diseases, cancer, neurological diseases or other diseases/disorders involving ROCKs and also for basic medical research. Moreover, the agents can be used for screening inhibitors against ROCKI and II.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: April 28, 2015
    Assignee: National Yang Ming University
    Inventors: Zee-Fen Chang, Hsiao-Hui Lee
  • REGENTS FOR PROBING ROCKS ACTIVATION
    Publication number: 20140030731
    Abstract: A set of agents is provided for probing/detecting the activation of Rho-associated protein kinase I and II individually encoding their amino acid sequence (SEQ ID NO:1 for ROCKI and SEQ ID NO:2 for ROCKII) in biological samples. The agents include one antibody to specifically recognize ROCKI Ser1333 phosphorylation and one antibody to specifically recognize ROCKII Ser1366 phosphorylation. The agents can be used for pathological analysis in cardiovascular diseases, cancer, neurological diseases or other diseases/disorders involving ROCKs and also for basic medical research. Moreover, the agents can be used for screening inhibitors against ROCKI and II.
    Type: Application
    Filed: November 27, 2012
    Publication date: January 30, 2014
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventors: Zee-Fen CHANG, Hsiao-Hui LEE
  • Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells
    Publication number: 20130252953
    Abstract: The present invention relates to novel TMPK inhibitor compositions and their methods of use. In particular, it relates to novel TMPK inhibitor compositions and therapeutics that lead to dUTP-mediated DNA repair in tumor cells and acts as a novel chemosensitizer, which are useful in methods for treating or preventing cancers.
    Type: Application
    Filed: November 29, 2011
    Publication date: September 26, 2013
    Inventors: Zee-Fen Chang, Jim-Min Fang, Chun-Mei Hu, Ming-Tyng Yeh
  • PROSTAGLANDIN REDUCTASE
    Publication number: 20080086000
    Abstract: An isolated polypeptide containing the sequence of SEQ ID NO:1 or a functional equivalent of SEQ ID NO:1, in which the polypeptide reduces 15-keto prostaglandin but not leukotriene B4. Also disclosed is an antibody that binds specifically to the polypeptide and a double-stranded ribonucleic acid for inhibiting expression of the 15-keto prostaglandin-?13-reductase.
    Type: Application
    Filed: October 5, 2007
    Publication date: April 10, 2008
    Inventors: Lee-Ming CHUANG, Zee-Fen CHANG, Wen-Ling CHOU