Abstract: The present disclosure provides compositions including at least one Dead Sea extract, ?-carotene and Niacinamide. The present disclosure further provides formulations including the compositions, their uses and methods utilizing same.

Abstract: Provided are compositions including at least one Dead Sea extract and at least one extract of the Apple of Sodom (Calotropis procera). Further provided are formulations including the compositions and their uses.

Abstract: Provided are compositions including at least one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. Further provided are formulations including the compositions and their uses as skin protectants against pollution.

Abstract: Provided are compositions including at least one Dead Sea extract and at least one extract of the Apple of Sodom (Calotropis Procera). Further provided are formulations including the compositions and their uses.

Abstract: Provided are compositions including at least one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. Further provided are formulations including the compositions and their uses as skin protectants against pollution.

Abstract: The present disclosure is directed to dispersions of a Dead Sea material in oil, the Dead Sea material is present in the dispersions in the form of solid nanoparticles. Further disclosed are formulations comprising the dispersions, method of treating and/or preventing diseases or disorders of the skin comprising topical application of the dispersions or formulations thereof onto a skin of a subject, method of inducing a heat sensation on the skin of a subject by topically applying the dispersions or formulations thereof onto a skin of a subject and methods of preparing the dispersions.

Abstract: The present disclosure provides method of inducing secretion of beta-endorphin in a skin region of a subject, the method comprises topically applying a composition comprising at least 0.5% Dead Sea Water onto a skin region of a subject. The disclosure further provides a method of modifying at least one condition of a skin region of a subject, the method comprises topically applying a composition comprising at least 0.5% Dead Sea Water onto the skin region of the subject, wherein the at least one skin condition is selected from the group consisting of mechanical and physiological skin condition and wherein the modifying of the at least one skin condition is associated with induction of skin beta-endorphin secretion in the skin region.

Abstract: The present disclosure is directed to dispersions of a Dead Sea material in oil, the Dead Sea material is present in the dispersions in the form of solid nanoparticles. Further disclosed are formulations comprising the dispersions, method of treating and/or preventing diseases or disorders of the skin comprising topical application of the dispersions or formulations thereof onto a skin of a subject, method of inducing a heat sensation on the skin of a subject by topically applying the dispersions or formulations thereof onto a skin of a subject and methods of preparing the dispersions.