Patents by Inventor Zefeng Wang

Zefeng Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHETIC SITE-SPECIFIC RNA EDITING ENTITIES
    Publication number: 20240002863
    Abstract: The present disclosure provides compositions comprising synthetic site-specific RNA editing entities engineered to target pathogenic RNA comprising a CAG repeat associated with a CAG repeat disorder. Also disclosed herein are methods of treating the CAG repeat disorders of the present disclosure, such as Huntington's disease with the compositions and pharmaceutical formulations comprising the compositions disclosed herein.
    Type: Application
    Filed: June 21, 2023
    Publication date: January 4, 2024
    Inventors: Joseph RUIZ, Zefeng WANG
  • RNA SITE-DIRECTED EDITING USING ARTIFICIALLY CONSTRUCTED RNA EDITING ENZYMES AND RELATED USES
    Publication number: 20220195416
    Abstract: Disclosed are RNA site-directed editing using artificially constructed RNA editing enzymes and related uses. Provided is the fusion of an RNA recognition domain for binding RNA and a functional effector domain to form a new functional protein. The new functional protein specifically targets target RNA by means of the recognition domain and performs RNA editing using the effector domain.
    Type: Application
    Filed: March 30, 2020
    Publication date: June 23, 2022
    Applicant: SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES
    Inventors: Zefeng WANG, Wenjian HAN
  • PROTEIN TRANSLATION USING CIRCULAR RNA AND APPLICATION THEREOF
    Publication number: 20220177898
    Abstract: Provided are a circular RNA construct and application thereof. The circular RNA construct has a structure represented by formula I in the 5?-3? direction: TI-Z1-Z2 (I), wherein TI is a translation initiation element, Z1 is an expression cassette for exogenous protein expression, and Z2 is nothing or another element.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 9, 2022
    Applicant: SHANGHAI INSTITUTE OF NUTRITION AND HEALTH, CHINESE ACADEMY OF SCIENCES
    Inventors: Zefeng WANG, Yun YANG, Xiaojuan FAN
  • METHODS AND COMPOSITIONS FOR SYNTHETIC RNA ENDONUCLEASES
    Publication number: 20210254042
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Application
    Filed: September 23, 2020
    Publication date: August 19, 2021
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • Methods and compositions for synthetic RNA endonucleases
    Patent number: 10815476
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: October 27, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • METHODS AND COMPOSITIONS FOR SYNTHETIC RNA ENDONUCLEASES
    Publication number: 20190153429
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Application
    Filed: June 28, 2018
    Publication date: May 23, 2019
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • Methods and Compositions for Synthetic RNA Endonucleases
    Publication number: 20180080018
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Application
    Filed: May 23, 2017
    Publication date: March 22, 2018
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • METHODS AND COMPOSITIONS FOR SYNTHETIC RNA ENDONUCLEASES
    Publication number: 20170137803
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 18, 2017
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • Methods and compositions for synthetic RNA endonucleases
    Patent number: 9499805
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: November 22, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Zefeng Wang, Rajarshi Choudhury
  • Methods and Compositions for Sequence Specific RNA Endonucleases
    Publication number: 20130129701
    Abstract: The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.
    Type: Application
    Filed: June 17, 2011
    Publication date: May 23, 2013
    Inventors: Zefeng Wang, Rajarshi Choudhury