Abstract: A sorting device based on an electric spark cavitation bubble includes: a liquid flow subsystem including a sheath flow channel, a sample flow channel, and a main flow channel, where the main flow channel is divided into a waste flow channel and a collection flow channel via a bifurcation port; a detecting subsystem configured to collect a pulse signal excited by the cell sample, and convert the pulse signal into an electrical signal; a data acquiring and processing subsystem configured to acquire and analyze the electrical signal, and issue a sorting instruction based on an analysis result; and a cavitation bubble generating subsystem configured to generate the cavitation bubble according to the sorting instruction, where the cavitation bubble pushes a liquid to generate a jet, and the bifurcation port is located within a range corresponding to the jet nozzle.